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Frontiers of Materials Science

ISSN 2095-025X

ISSN 2095-0268(Online)

CN 11-5985/TB

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Front. Mater. Sci.    2015, Vol. 9 Issue (2) : 192-198    https://doi.org/10.1007/s11706-015-0294-8
RESEARCH ARTICLE
Co-substitution of carbonate and fluoride in hydroxyapatite: Effect on substitution type and content
Qing-Xia ZHU(),Ya-Ming LI,Dan HAN
School of Materials Science and Engineering, Jingdezhen Ceramic Institute, Jingdezhen 333001, China
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Abstract

The nanosized hydroxyapatite substituted by fluoride and carbonate ions (CFHA) had been synthesized by aqueous precipitation method. CFHA had been considered as potential bone graft material for orthopedic and dental applications. The objective of this study was to determine the effects of simultaneously incorporated CO2--3 and F-- on the substitution type and content. The morphologies of CFHAs were observed by TEM. The carbonate substitution type and content were characterized by FTIR. The fluoride contents were determined by F-selective electrode. The phase compositions and crystallinity of the samples were investigated by XRD. The fluoride and carbonate contents of CFHA increase with the dopant concentrations nonlinearly. The carbonate substitution has much more obvious effect on morphology compared with the fluoride substitution. The co-existence of CO2--3 and F-- ions can influence the corresponding substitution fraction. The isomorphic substitution of sodium for calcium in the substitution process of CO2--3 can improve crystal degree and favor the B-type substitutions. Due to the closeness of the ion radii and equivalent substitution of F-- and OH--, F-- will occupy the OH-- sites of HA crystals more easily, compelling most of the CO2--3 to be located in the B sites.
Keywords hydroxyapatite      co-substitution      carbonate      fluoride      substitution type      substitution content     
Corresponding Author(s): Qing-Xia ZHU   
Online First Date: 21 April 2015    Issue Date: 23 July 2015
 Cite this article:   
Qing-Xia ZHU,Ya-Ming LI,Dan HAN. Co-substitution of carbonate and fluoride in hydroxyapatite: Effect on substitution type and content[J]. Front. Mater. Sci., 2015, 9(2): 192-198.
 URL:  
https://academic.hep.com.cn/foms/EN/10.1007/s11706-015-0294-8
https://academic.hep.com.cn/foms/EN/Y2015/V9/I2/192
Sample n( C O 3 2 - )/n( P O 4 3 - ) n(F-)/n(Ca2+) With/without Na Fluoride content /wt.% Carbonate content /wt.%
C3F4Na 0.03 0.04 with 0.424 3.20
C3F8Na 0.03 0.08 with 0.679 3.19
C3F12Na 0.03 0.12 with 1.373 3.14
C11F4Na 0.11 0.04 with 0.392 6.19
C11F8Na 0.11 0.08 with 0.628 6.16
C11F12Na 0.11 0.12 with 1.268 6.13
C22F4Na 0.22 0.04 with 0.362 8.21
C22F8Na 0.22 0.08 with 0.558 8.17
C22F12Na 0.22 0.12 with 1.223 8.15
C22F4 0.22 0.04 without 0.441 7.21
C22F8 0.22 0.8 without 0.679 7.18
C3F12 0.03 0.12 without 1.223 2.13
HA 0 0 with - -
C3HA 0.03 0 with - 3.23
Tab.1  The dopant concentration and the substitution content of samples
Fig.1  TEM photographs of CFHAs prepared at different dopant concentrations: (a) C3F4Na; (b) C22F12Na; (c) C22F4Na; (d) C3F12Na.
Fig.2  FTIR spectra of the apatites prepared at different dopant concentrations: HA (a); C3HA (b); C3F4Na (c); C22F12Na (d); C22F4Na (e); C3F12Na (f).
Fig.3  FTIR spectra of CFHAs using NH4HCO3 or NaHCO3 as reactants introducing CO3 groups.
Fig.4  XRD patterns of CFHAs using NH4HCO3 or NaHCO3 as reactants introducing CO3 groups.
Fig.5  FTIR spectra of CFHAs with different adding order of fluoride and carbonate.
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