Chitosan-collagen/organomontmorillonite scaffold for bone tissue engineering

doi:10.1007/s11706-015-0317-5

Front. Mater. Sci.

2015, Vol. 9

Issue (4) : 405-412 https://doi.org/10.1007/s11706-015-0317-5

RESEARCH ARTICLE

Chitosan-collagen/organomontmorillonite scaffold for bone tissue engineering

Xianshuo CAO¹,Jun WANG²,Min LIU¹,Yong CHEN¹,Yang CAO¹,Xiaolong YU^1,^*(

)

1. College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China
2. College of Ocean, Hainan University, Haikou 570228, China

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Abstract

A novel composite scaffold based on chitosan-collagen/organomontmo-rillonite (CS-COL/OMMT) was prepared to improve swelling ratio, biodegradation ratio, biomineralization and mechanical properties for use in tissue engineering applications. In order to expend the basal spacing, montmorillonite (MMT) was modified with sodium dodecyl sulfate (SDS) and was characterized by XRD, TGA and FTIR. The results indicated that the anionic surfactants entered into interlayer of MMT and the basal spacing of MMT was expanded to 3.85 nm. The prepared composite scaffolds were characterized by FTIR, XRD and SEM. The swelling ratio, biodegradation ratio and mechanical properties of composite scaffolds were also studied. The results demonstrated that the scaffold decreased swelling ratio, degradation ratio and improved mechanical and biomineralization properties because of OMMT.

Keywords chitosan (CS) collagen (COL) montmorillonite (MMT) sodium dodecyl sulfate (SDS)

Corresponding Author(s): Xiaolong YU

Online First Date: 06 November 2015 Issue Date: 12 November 2015

Cite this article:

Xianshuo CAO,Jun WANG,Min LIU, et al. Chitosan-collagen/organomontmorillonite scaffold for bone tissue engineering[J]. Front. Mater. Sci., 2015, 9(4): 405-412.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-015-0317-5
https://academic.hep.com.cn/foms/EN/Y2015/V9/I4/405

Fig.1 FTIR spectra of CS, COL, MMT, OMMT, SDS and scaffolds.

Fig.2 XRD patterns of MMT, SDS, and OMMT.

Fig.3 TGA curves of MMT, SDS, OMMT, CS, COL, and scaffolds.

Fig.4 DSC curves of MMT, SDS, OMMT, CS, COL, and scaffolds.

Fig.5 SEM images of (a) CS-COL, (b) CS-COL/MMT, and (c) CS-COL/OMMT.

Fig.6 SEM-EDS images of (a) MMT and (b) OMMT.

Fig.7 Swelling ratios of the scaffolds in PBS.

Fig.8 Biodegradation behavior of the scaffolds.

Fig.9 Compressive stress–strain curves of scaffolds.

Fig.10 SEM images for mineralization of scaffolds in SBF after 7 d: (a) CS-COL; (b) CS-COL/MMT; (c) CS-COL/OMMT.

Tab.1

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