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The multifunctional wound dressing with core–shell structured fibers prepared by coaxial electrospinning |
Qilin WEI1,Feiyang XU1,Xingjian XU1,Xue GENG1,2,Lin YE1,2,*(),Aiying ZHANG1,2,Zengguo FENG1,2 |
1. School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China 2. Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, Beijing 100081, China |
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Abstract The non-woven wound dressing with core–shell structured fibers was prepared by coaxial electrospinning. The polycaprolactone (PCL) was electrospun as the fiber’s core to provide mechanical strength whereas collagen was fabricated into the shell in order to utilize its good biocompatibility. Simultaneously, the silver nanoparticles (Ag-NPs) as anti-bacterial agent were loaded in the shell whereas the vitamin A palmitate (VA) as healing-promoting drug was encapsulated in the core. Resulting from the fiber’s core–shell structure, the VA released from the core and Ag-NPs present in the shell can endow the dressing both heal-promoting and anti-bacteria ability simultaneously, which can greatly enhance the dressing’s clinical therapeutic effect. The dressing can maintain high swelling ratio of 190% for 3 d indicating its potential application as wet dressing. Furthermore, the dressing’s anti-bacteria ability against Staphylococcus aureus was proved by in vitro anti-bacteria test. The in vitro drug release test showed the sustainable release of VA within 72 h, while the cell attachment showed L929 cells can well attach on the dressing indicating its good biocompatibility. In conclusion, the fabricated nanofibrous dressing possesses multiple functions to benefit wound healing and shows promising potential for clinical application.
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Keywords
coaxial electrospinning
core–shell structure
multifunctional wound dressing
anti-bacteria
heal-promoting
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Corresponding Author(s):
Lin YE
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Online First Date: 22 April 2016
Issue Date: 11 May 2016
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