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Frontiers of Materials Science

ISSN 2095-025X

ISSN 2095-0268(Online)

CN 11-5985/TB

Postal Subscription Code 80-974

2018 Impact Factor: 1.701

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Front. Mater. Sci.    2016, Vol. 10 Issue (3) : 281-289    https://doi.org/10.1007/s11706-016-0345-9
RESEARCH ARTICLE
Blood compatibility of zinc–calcium phosphate conversion coating on Mg–1.33Li–0.6Ca alloy
Yu-Hong ZOU1,Rong-Chang ZENG2,4,*(),Qing-Zhao WANG1,Li-Jun LIU2,Qian-Qian XU3,Chuang WANG1,Zhiwei LIU1
1. College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, China
2. College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China
3. Hospital of Shandong University of Science and Technology, Qingdao 266590, China
4. State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China
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Abstract

Magnesium alloys as a new class of biomaterials possess biodegradability and biocompatibility in comparison with currently used metal implants. However, their rapid corrosion rates are necessary to be manipulated by appropriate coatings. In this paper, a new attempt was used to develop a zinc–calcium phosphate (Zn–Ca–P) conversion coating on Mg–1.33Li–0.6Ca alloys to increase the biocompatibility and improve the corrosion resistance. In vitro blood biocompatibility of the alloy with and without the Zn–Ca–P coating was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed from the hemolysis test, the dynamic cruor time test, blood cell count and SEM observation of the platelet adhesion to membrane surface. The results showed that the Zn–Ca–P coating on Mg–1.33Li–0.6Ca alloys had good blood compatibility, which is in accordance with the requirements for medical biomaterials.
Keywords magnesium alloy      lithium      zinc–calcium phosphate coating      biocompatibility      biomaterial     
Corresponding Author(s): Rong-Chang ZENG   
Online First Date: 12 June 2016    Issue Date: 08 August 2016
 Cite this article:   
Yu-Hong ZOU,Rong-Chang ZENG,Qing-Zhao WANG, et al. Blood compatibility of zinc–calcium phosphate conversion coating on Mg–1.33Li–0.6Ca alloy[J]. Front. Mater. Sci., 2016, 10(3): 281-289.
 URL:  
https://academic.hep.com.cn/foms/EN/10.1007/s11706-016-0345-9
https://academic.hep.com.cn/foms/EN/Y2016/V10/I3/281
Fig.1  (a) SEM image of the Zn–Ca–P coating on the Mg–1.33Li–0.6Ca alloy and (b) EDS results of the Zn–Ca–P coating composite.
Fig.2  Hydrogen evolution rates for pure Mg, the Mg–1.33Li–0.6Ca alloy and the Zn–Ca–P coating immersed for 10 h in Hank’s solution.
Fig.3  The pH values for pure Mg, the Mg–1.33Li–0.6Ca alloy and the Zn–Ca–P coating immersed for 120 h in Hank’s solution.
Fig.4  Absorbance values for pure Mg, the Mg–1.33Li–0.6Ca alloy and the Zn–Ca–P coating.
Fig.5  Hemolysis ratios for pure Mg, the Mg–1.33Li–0.6Ca alloy and the Zn–Ca–P coating.
Fig.6  Comparison of reduction of blood cells on the surfaces of pure Mg (a), the Mg–1.33Li–0.6Ca alloy (b) and the Zn–Ca–P coating (c) samples (*p>0.05).
Fig.7  Reduction of blood cells on the surfaces of pure Mg, the Mg–1.33Li–0.6Ca alloy and the Zn–Ca–P coating samples (% of initial blood cells).
Fig.8  Dynamic clotting time curves of pure Mg, the Mg–1.33Li–0.6Ca alloy and the Zn–Ca–P coating.
Fig.9  SEM images of blood platelets adhesion on (a) pure Mg, (b) the Mg–1.33Li–0.6Ca alloy and (c) the Zn–Ca–P coating.
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