Fabrication of h-MnO<sub>2</sub>@PDA composite nanocarriers for enhancement of anticancer cell performance by photo-chemical synergetic therapies

doi:10.1007/s11706-021-0553-9

Front. Mater. Sci.

2021, Vol. 15

Issue (2) : 291-298 https://doi.org/10.1007/s11706-021-0553-9

LETTER

Fabrication of h-MnO₂@PDA composite nanocarriers for enhancement of anticancer cell performance by photo-chemical synergetic therapies

Xue-ya ZHANG¹, Guo-hua JIANG¹(

), Gao SONG¹, Tian-qi LIU¹, Yan-fang SUN²(

), Zhi-yong ZENG¹

¹. School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
². College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China

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Corresponding Author(s): Guo-hua JIANG,Yan-fang SUN

Online First Date: 14 May 2021 Issue Date: 08 June 2021

Cite this article:

Xue-ya ZHANG,Guo-hua JIANG,Gao SONG, et al. Fabrication of h-MnO₂@PDA composite nanocarriers for enhancement of anticancer cell performance by photo-chemical synergetic therapies[J]. Front. Mater. Sci., 2021, 15(2): 291-298.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-021-0553-9
https://academic.hep.com.cn/foms/EN/Y2021/V15/I2/291

Fig.1 Scheme 1 (a) Schematic diagram for the synthesis of DOX/h-MnO₂@PDA nanoparticles. (b) Schematic diagram of the endocytosis of DOX/h-MnO₂@PDA nanoplatforms for CT, CDT and PTT.

Fig.2 SEM and TEM images of (a)(b) SiO₂, (c)(d) SiO₂@MnO₂, (e)(f) h-MnO₂, and (g)(h) h-MnO₂@PDA NPs. (i) XRD pattern of h-MnO₂ and (j) N₂ absorption–desorption curves of h-MnO₂@PDA (inset: porous size distribution curve).

Fig.3 Photothermal properties of h-MnO₂@PDA NPs: (a) thermal images of h-MnO₂@PDA solution at different concentrations (0, 50, 100, 200, 400 μg·mL⁻¹) under the NIR irradiation (808 nm, 1.0 W·cm⁻²) at 0 and 10 min; (b) temperature increase curves of h-MnO₂@PDA dispersed in water under the NIR irradiation for 10 min; (c) temperature evolution of h-MnO₂@PDA solution (400 μg·mL⁻¹) during four NIR on/off cycles.

Fig.4 (a) DOX release from DOX/h-MnO₂@PDA in the PBS buffer at different pH values (7.4, 6.5 and 5.5). (b) UV–vis absorbance spectra of methylene blue (black curve) after the addition of different concentrations of h-MnO₂@PDA. (c) Cell viability of MCF-7 cells treated with NIR (10 min), h-MnO₂@PDA (200 μg·mL⁻¹), h-MnO₂@PDA (200 μg·mL⁻¹) + NIR (10 min), free DOX (2.5 μg·mL⁻¹), DOX/h-MnO₂@PDA (200 μg·mL⁻¹), and DOX/h-MnO₂@PDA (200 μg·mL⁻¹) + NIR (10 min). (d) CLSM images of MCF-7 cells treated with free, h-MnO₂@PDA and DOX/h-MnO₂@PDA for 6 h. (e) The level of intracellular ROS monitored by a peroxide-sensitive DCFH-DA fluorescent staining.

Fig. S1 EDS results of h-MnO₂@PDA.

Fig. S2 XPS results of h-MnO₂@PDA: (a) full scan; (b)Mn 2p spectrum; (c) O 1s spectrum; (d) N 1s spectrum.

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