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Frontiers of Physics

ISSN 2095-0462

ISSN 2095-0470(Online)

CN 11-5994/O4

邮发代号 80-965

2019 Impact Factor: 2.502

Frontiers of Physics  2012, Vol. 7 Issue (5): 576-581   https://doi.org/10.1007/s11467-012-0261-0
  PERSPECTIVE 本期目录
Understanding the physics of DNA using nanoscale single-molecule manipulation
Understanding the physics of DNA using nanoscale single-molecule manipulation
Eric W. Frey, Ashton A. Gooding, Sitara Wijeratne, Ching-Hwa Kiang()
1Department of Physics and Astronomy,Rice University, Houston, TX 77005, USA
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Abstract

Processes for decoding the genetic information in cells, includingtranscription, replication, recombination and repair, involve thedeformation of DNA from its equilibrium structures such as bending,stretching, twisting, and unzipping of the double helix. Single-moleculemanipulation techniques have made it possible to control DNA conformationand simultaneously detect the induced changes, revealing a rich varietyof mechanically-induced conformational changes and thermodynamic states.These single-molecule techniques helped us to reveal the physics ofDNA and the processes involved in the passing on of the genetic code.

Key wordssingle-molecule manipulation    the physics of DNA
收稿日期: 2012-05-24      出版日期: 2012-10-01
Corresponding Author(s): Kiang Ching-Hwa,Email:chkiang@rice.edu   
 引用本文:   
. Understanding the physics of DNA using nanoscale single-molecule manipulation[J]. Frontiers of Physics, 2012, 7(5): 576-581.
Eric W. Frey, Ashton A. Gooding, Sitara Wijeratne, Ching-Hwa Kiang. Understanding the physics of DNA using nanoscale single-molecule manipulation. Front. Phys. , 2012, 7(5): 576-581.
 链接本文:  
https://academic.hep.com.cn/fop/CN/10.1007/s11467-012-0261-0
https://academic.hep.com.cn/fop/CN/Y2012/V7/I5/576
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