Regulation of 1, 4, 5-triphosphate receptor channel gating dynamics by mutant presenilin in Alzheimer’s disease cells

doi:10.1007/s11467-017-0670-1

Frontiers of Physics

2017, Vol. 12

Issue (3): 128702 https://doi.org/10.1007/s11467-017-0670-1

本期目录

Regulation of 1, 4, 5-triphosphate receptor channel gating dynamics by mutant presenilin in Alzheimer’s disease cells

Fang Wei¹,Xiang Li²,Meichun Cai¹,Yanping Liu¹,Peter Jung³,Jianwei Shuai^1,^2,⁴(

)

¹. Department of Physics, Xiamen University, Xiamen 361005, China
². State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361005, China
³. Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, OH 45701, USA
⁴. Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen 361005, China

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Abstract：

In neurons of patients with Alzheimer’s disease, the intracellular Ca²⁺ concentration is increased by its release from the endoplasmic reticulum via the inositol 1, 4, 5-triphosphate receptor (IP₃R). In this paper, we discuss the IP₃R gating dynamics in familial Alzheimer’s disease (FAD) cells induced with mutation PS1. By fitting the parameters of an IP₃R channel model to experimental data of the open probability, the mean open time and the mean closed time of IP₃R channels, in control cells and FAD mutant cells, we suggest that the interaction of presenilin mutation PS1 with IP₃R channels leads the decrease in the unbinding rates of IP₃ and the activating Ca²⁺ from IP₃Rs. As a result, the increased affinities of IP₃ and activating Ca²⁺ for IP₃R channels induce the increase in the Ca²⁺ signal in FAD mutant cells. Specifically, the PS1 mutation decreases the IP₃ dissociation rate of IP₃R channels significantly in FAD mutant cells. Our results suggest possible novel targets for FAD therapeutic intervention.

Key words： Ca²⁺ signal channel neuron Alzheimer’s disease

收稿日期: 2016-10-31 出版日期: 2017-03-17

Corresponding Author(s): Jianwei Shuai

引用本文:

. [J]. Frontiers of Physics, 2017, 12(3): 128702.
Fang Wei,Xiang Li,Meichun Cai,Yanping Liu,Peter Jung,Jianwei Shuai. Regulation of 1, 4, 5-triphosphate receptor channel gating dynamics by mutant presenilin in Alzheimer’s disease cells. Front. Phys. , 2017, 12(3): 128702.

链接本文:

https://academic.hep.com.cn/fop/CN/10.1007/s11467-017-0670-1
https://academic.hep.com.cn/fop/CN/Y2017/V12/I3/128702

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