We propose an efficient scheme to implement a multiplex-controlled phase gate with multiple photonic qubits simultaneously controlling one target photonic qubit based on circuit quantum electrodynamics (QED). For convenience, we denote this multiqubit gate as MCP gate. The gate is realized by using a two-level coupler to couple multiple cavities. The coupler here is a superconducting qubit. This scheme is simple because the gate implementation requires only one step of operation. In addition, this scheme is quite general because the two logic states of each photonic qubit can be encoded with a vacuum state and an arbitrary non-vacuum state |φ> (e.g., a Fock state, a superposition of Fock states, a cat state, or a coherent state, etc.) which is orthogonal or quasi-orthogonal to the vacuum state. The scheme has some additional advantages: because only two levels of the coupler are used, i.e., no auxiliary levels are utilized, decoherence from higher energy levels of the coupler is avoided; the gate operation time does not depend on the number of qubits; and the gate is implemented deterministically because no measurement is applied. As an example, we numerically analyze the circuit-QED based experimental feasibility of implementing a three-qubit MCP gate with photonic qubits each encoded via a vacuum state and a cat state. The scheme can be applied to accomplish the same task in a wide range of physical system, which consists of multiple microwave or optical cavities coupled to a two-level coupler such as a natural or artificial atom.