A review of the decades of research shows that Chinese philosophy of science and technology, on the strength of carrying forward traditions and blazing new trails, has made progress in the construction of discipline system and development of institutions, teaching materials and periodicals, with deepening the discussion on discipline orientation. In academic system construction, driven by efforts to update the academic framework and deepen research on the philosophy of nature, philosophy of science, philosophy of technology, science, technology and society, as well as other traditional fields, achievements have been made in ethical reflections on high technology, engineering ethics, big data and artificial intelligence philosophy, responsible innovation and other emerging, frontier and crosscutting fields. In the construction of discourse system, work has been done to make China’s voice heard on the international stage, excavate and elucidate the excellent traditional Chinese culture, and build disciplines with Chinese characteristics. In short, the achievements of the Chinese philosophy of science and technology have not come easily. Though a diverse and dynamic academic pattern has been formed, and wonderful and unique Chinese discourse has been created, we still face some problems. To accelerate the construction of “Three Systems” of the philosophy of science and technology with Chinese characteristics by building on existing achievements, we should carry forward the tradition of dialectics of nature and strengthen the guidance of Marxism, consolidate the foundation of philosophy and support interdisciplinary interaction and cooperation, track the frontiers of science and technology, and pay attention to the social operation of science and technology.