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Neuropsychology in ischemic stroke:stress,allostasis and allostatic load |
| Ling Guan1,2,3 Jean-Paul Collet1,2,3 |
| 1. Department of Medicine, The University of British Columbia,Vancouver V5Z 1M9, Canada
2. Department of Pediatrics, The University of British Columbia, Vancouver V6H 0B3, Canada
3. BC Children’s Hospital Research Institute, The University of British Columbia,Vancouver V5Z 4H4, Canada |
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Abstract As a complicated cerebrovascular disorder,ischemic stroke involves a series of mind-body connections. The “stress” refers to a state of threatened homeostasis caused by any form of internal or external disturbing forces. The “stress response” is a counteracting force that neutralizes the effects of stressors and re-establish homeostasis, which may cause two different outcomes, the allostasis and allostatic load. The prompt stress system is the autonomic nervous system (ANS) with two branches the sympathetic (SNS) and parasympathetic (PNS) nervous systems that play an important role in regulating stress response. As a typical example and final endpoint of allostatic load, ischemic stroke and its complications are related to stress and autonomic dysfunction.Different clinical tests are described for assessing autonomic function in ischemic stroke. This review may bring possibilities for future study to investigate specific treatment on ANS function and stress management on the context of traditional stroke therapies, and thus help improve the clinical outcomes and prognosis of ischemic stroke.
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| Keywords
ischemic stroke
stress
allostasis
allostatic load
autonomic nervous system
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Issue Date: 15 October 2017
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