Latest progress in the research of protein kinase C (PKC) isoform-specific signaling and PKC-modulated autophagy in ischemic stroke

doi:10.3868/j.issn.2096-0689.2017.02.003

Journal of Translational Neuroscience

2017, Vol. 2

Issue (2) : 16-24 https://doi.org/10.3868/j.issn.2096-0689.2017.02.003

Review

Latest progress in the research of protein kinase C (PKC) isoform-specific signaling and PKC-modulated autophagy in ischemic stroke

Rongrong Hua, Nan Zhang, Yanling Yin, Junfa Li

Department of Neurobiology and Center of Stroke, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China

Download: PDF(10586 KB)
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Abstract Ischemic stroke is a major cause of morbidity and mortality, and currently there is no effective treatment. The family of protein kinase C (PKCs) could phosphorylate serine or threonine residues of its substrate proteins and play a key role in the ischemia/reperfusion injury. Autophagy is essential for maintaining cell homeostasis under physiological condition and acts as a double-edged sword in the process of ischemic neuronal death. In this article, we reviewed the PKCs isoform-specific signaling pathways and PKC-modulated autophagy in ischemic stroke.

Keywords protein kinase C(PKC) autophagy ischemic stroke

Issue Date: 15 October 2017

Cite this article:

Rongrong Hua, Nan Zhang, Yanling Yin, Junfa Li. Latest progress in the research of protein kinase C (PKC) isoform-specific signaling and PKC-modulated autophagy in ischemic stroke[J]. Journal of Translational Neuroscience,2017, 2(2): 16-24.

URL:

https://academic.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2017.02.003
https://academic.hep.com.cn/jtn/EN/Y2017/V2/I2/16

[1]	Yi Bao, Lixia Ma, Xiaodong Liu, Guangjian Liu, Ying Wang. Clinical characteristics and treatment strategies of acute ischemic stroke with internal carotid artery occlusion: a case report[J]. Journal of Translational Neuroscience, 2019, 4(2): 31-38.
[2]	Ling Guan, Jean-Paul Collet. Neuropsychology in ischemic stroke:stress,allostasis and allostatic load[J]. Journal of Translational Neuroscience, 2017, 2(2): 1-6.

Viewed

Full text

Abstract

Cited

Shared

Discussed