Recommendation for and comparison of three types of dementia: Alzheimer’s disease, subcortical ischemic vascular dementia, and mixed dementia

doi:10.3868/j.issn.2096-0689.2017.03.003

Journal of Translational Neuroscience

2017, Vol. 2

Issue (3) : 15-25 https://doi.org/10.3868/j.issn.2096-0689.2017.03.003

Review

Recommendation for and comparison of three types of dementia: Alzheimer’s disease, subcortical ischemic vascular dementia, and mixed dementia

Lu Shi¹, Jianping Jia^1-6*

1. Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
2. Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China
3. Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing 100053, China
4. Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100053, China
5. Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China
6. National Clinical Research Center for Geriatric Disorders, Beijing 100053, China

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Abstract With the progress in global demography of aging, dementia has become a great world health-care issue that require urgent attention and settlement. Dementia can arise from a variety of factors, such as neuronal degeneration for Alzheimer’s disease (AD), vascular risk factors and multiple infarcts for vascular dementia (VaD), and both degeneration and vascular factors for mixed dementia (MD). Pathophysiology of AD includes the amyloid and tau protein hypothesis, and inflammation-related mechanisms are also widespread mentioned. Subcortical ischemic vascular dementia (SIVD), a subtype of VaD, is commonly caused by complete or incomplete lacunar infarction of VaD pathology. MD involves both degeneration and vascular factors, and the interaction between the two results in the complication of the pathological mechanism and clinical phenotype. The clinical manifestations of AD are often divided into four stages according to the progress of the disease, while the phenotypes of SIVD usually has two categories. As for MD, the phenotypes are complex and diverse. Several clinical studies showed that its symptoms and signs are more similar to SIVD than AD. This article aims to analyze and compare the different aspects of the three kinds of dementia.

Keywords Alzheimer’s disease (AD) subcortical ischemic vascular dementia (SIVD) mixed dementia (MD) pathophysiology clinical feature

Issue Date: 25 November 2017

Cite this article:

Lu Shi, Jianping Jia. Recommendation for and comparison of three types of dementia: Alzheimer’s disease, subcortical ischemic vascular dementia, and mixed dementia[J]. Journal of Translational Neuroscience,2017, 2(3): 15-25.

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https://academic.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2017.03.003
https://academic.hep.com.cn/jtn/EN/Y2017/V2/I3/15

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