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Disrupted functional connectivity of default mode network and executive control network in patients with vascular cognitive impairment, no dementia |
| Tan Zhao1, Jianping Jia1-6* |
1. Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
2. Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China
3. Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing 100053, China
4. Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100053, China
5. Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China
6. National Clinical Research Center for Geriatric Disorders, Beijing 100053, China |
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Abstract Objective: To investigate functional connectivity within default mode network (DMN) and executive control network (ECN) in vascular cognitive impairment, no dementia (VCIND). Methods: Twenty-eight VCIND patients and sixteen healthy controls were recruited. A seed-based connectivity analysis was performed using data from resting-state functional magnetic resonance imaging (fMRI). Based on previous findings, posterior cingulate cortex (PCC) and dorsolateral prefrontal cortex (DLPFC) were chosen as regions of interest to study these networks. One-sample t-test and two-sample t-test were used for statistical analysis. Results: Compared with the controls, the VCIND group exhibited increased functional activity in such DMN regions as the left inferior temporal gyrus, parahippocampal gyrus, and medial frontal gyrus. The VCIND group had decreased functional connectivity of DMN at right superior frontal gyrus, left mid-cingulate area, the medial part of left superior frontal gyrus, and bilateral medial frontal gyrus. The VCIND group also showed decreased functional connectivity of ECN primarily at left inferior parietal gyrus, right angular gyrus, right middle occipital gyrus, and right middle frontal cortex. Conclusions: Increased functional connectivity within DMN and decreased functional connectivity within ECN suggested dysfunction of these two networks, which might be associated with the cognitive deficits in patients with VCIND. These findings may help us understand the pathogenesis and clinical characteristics of VCIND.
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| Keywords
vascular cognitive impairment (VCI)
VCI no dementia (VCIND)
functional connectivity
default mode network
executive control network
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Issue Date: 25 November 2017
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