Challenges faced for undertaking a stem cell based clinical trial in spinal cord injury in emerging countries

doi:10.3868/j.issn.2096-0689.2018.03.001

Journal of Translational Neuroscience

2018, Vol. 3

Issue (3) : 1-8 https://doi.org/10.3868/j.issn.2096-0689.2018.03.001

Review

Challenges faced for undertaking a stem cell based clinical trial in spinal cord injury in emerging countries

Harvinder Singh Chhabra^*, Kanchan Sarda

Spine Service, Indian Spinal Injuries Center, Sector-C, Vasant Kunj, New Delhi 110070, India

Download: PDF(9770 KB)
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Abstract Repair and regeneration after spinal cord injury (SCI) is an unmet need and research into finding new avenues to achieve this are ongoing worldwide. Stem cells with their immense potential to proliferate and differentiate have been identified as prime candidates for spinal cord regeneration. Pre-clinical data on their efficacy has been very encouraging, especially in case of adult stem cells. Although clinical translation of these findings has not been so successful, due to the ease of obtaining autologous adult bone marrow stem cells and their perceived therapeutic potential, these cells have been offered as a “therapy” in many countries without any scientific evidence generated though a valid clinical trial. In this review, we attempt to highlight the need for conducting clinical trials and the challenges faced in case of emerging countries. The current scenario of regulations governing the use of stem cells in emerging countries is also discussed.

Keywords stem cells emerging countries spinal cord injury (SCI) regulations clinical trial

Issue Date: 25 November 2018

Cite this article:

Harvinder Singh Chhabra, Kanchan Sarda. Challenges faced for undertaking a stem cell based clinical trial in spinal cord injury in emerging countries[J]. Journal of Translational Neuroscience,2018, 3(3): 1-8.

URL:

https://academic.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2018.03.001
https://academic.hep.com.cn/jtn/EN/Y2018/V3/I3/1

[1]	Qianxu Jin, Zongmao Zhao. Human umbilical cord mesenchymal stem cells as cell carriers in the treatment of gliomas: research status and prospects[J]. Journal of Translational Neuroscience, 2020, 5(2): 22-33.
[2]	Yingli Jing, Fan Bai, Yan Yu. Role of melatonin in spinal cord injury[J]. Journal of Translational Neuroscience, 2018, 3(3): 26-31.
[3]	Erica L McGrath, Ping Wu. Adult brain neural stem cells: technological and translational advances[J]. Journal of Translational Neuroscience, 2017, 2(1): 10-17.

Viewed

Full text

Abstract

Cited

Shared

Discussed