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Journal of Translational Neuroscience(转化神经科学电子杂志)

ISSN 2096-0689

CN 11-9363/R

Journal of Translational Neuroscience    2020, Vol. 5 Issue (4) : 10-19    https://doi.org/10.3868/j.issn.2096-0689.2020.04.002
Review
Research progress for microRNA in the pathological mechanism of brain injury after stroke
Zhimin Sun, Xiaoli Sun*
Department of Neurosurgery, The Third Hospital of Shijiazhuang, Shijiazhuang 050000, China
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Abstract Ischemic stroke is a leading cause of death and disability. Despite extensive research, treatment for ischemic stroke is limited to thrombolytic therapy and symptom management. Identifying and testing new therapeutic targets is therefore critical for future clinically viable stroke therapies. Noncoding RNAs, especially microRNAs (miRNAs), are one of many classes of molecules that cause functional changes before, during, and after ischemic stroke. Current research finds that expression levels of many miRNAs are altered in the blood and brain of rodents and humans after stroke. In addition, miRNA can be regulated by external factors to improve functional outcomes after ischemic stroke. In certain studies, induction of ischemic tolerance by preconditioning (PC) also altered the levels of many miRNAs. This review focuses on miRNAs that modulate stroke-related risk factors and pathologic mechanisms of post-stroke brain injury.
Keywords microRNA (miRNA)      ischemic stroke      modulation      inflammation      oxidative stress      neurogenesis      angiogenesis     
Issue Date: 25 December 2020
 Cite this article:   
Zhimin Sun, Xiaoli Sun. Research progress for microRNA in the pathological mechanism of brain injury after stroke[J]. Journal of Translational Neuroscience,2020, 5(4): 10-19.
 URL:  
https://academic.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2020.04.002
https://academic.hep.com.cn/jtn/EN/Y2020/V5/I4/10
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