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A survey of research in brain iron level and Alzheimer’s disease |
| Xingguang Li1†, Chang Wang2†, Xiuxia Li1, Caipeng Cao1, Hongbo Shang1, Yongchuan Wang1, Tianyu Dong2* |
1.Yuanshi Hospital of Traditional Chinese Medicine, Shijiazhuang 051130, China
2.Hebei Medical University, Shijiazhuang 050000, China |
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Abstract The main pathological feature of Alzheimer’s disease (AD) is the extracellular deposition of β-amyloid (Aβ) in the brain, which forms insoluble Aβ plaques, and tau protein hyperphosphorylation in neurons, which forms intracellular fibrillary tangles. So far, none of the drugs targeting Aβ have been successful in the treatment of AD. Some studies have shown that brain iron deposition may be one of the important factors in AD pathogenesis; the distribution of iron deposition has been found to be consistent with the distribution of Aβ senile plaques in the brain. Effectively reducing brain iron load might therefore be a good therapeutic approach to prevent and treat AD.
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| Keywords
Alzheimer’s disease (AD)
iron overload
β-amyloid (Aβ)
oxidative stress
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Issue Date: 25 December 2020
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