Research progress of the synapsin 2 gene polymorphism in the pathogenesis of schizophrenia

doi:10.3868/j.issn.2096-0689.2022.01.001

Journal of Translational Neuroscience

2022, Vol. 7

Issue (1) : 1-5 https://doi.org/10.3868/j.issn.2096-0689.2022.01.001

Special Topic: Research Progress of Schizophrenia Related Genes

Research progress of the synapsin 2 gene polymorphism in the pathogenesis of schizophrenia

Zhilan Yang, Hongying Pan, Lan Jiang, Yuhang Liang, Jie Wu^*

Department of Clinical Psychology, The Affiliated Mental Hospital of Kunming Medical University, Kunming 650000, China

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Abstract Schizophrenia (SCZ) is the most common serious mental illness with a high disability rate and heavy social and family burdens. At present, there is no clear etiology and pathogenesis of schizophrenia. Studies have shown that the occurrence of schizophrenia may be related to the abnormality of the hypothalamic-pituitary-adrenal (HPA) axis. The LIM-homeobox gene 3 (LHX3) and early growth response 1 (EGR1) can affect pituitary function. Because the synapsin 2 (SYN2) gene polymorphism regulates the activity of LHX3 and EGR1, it may cause the occurrence of schizophrenia. This article will review the possible involvement of SYN2 gene polymorphism in the pathogenesis of schizophrenia via regulating the activity of LHX3 and EGR1, then to affect the HPA axis.

Keywords schizophrenia (SCZ) hypothalamic-pituitary-adrenal (HPA) axis synapsin 2 (SYN2) LIM-homeobox gene 3 (LHX3) early growth response 1 (EGR1)

Issue Date: 23 November 2022

Cite this article:

Zhilan Yang, Hongying Pan, Lan Jiang, Yuhang Liang, Jie Wu. Research progress of the synapsin 2 gene polymorphism in the pathogenesis of schizophrenia[J]. Journal of Translational Neuroscience,2022, 7(1): 1-5.

URL:

https://academic.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2022.01.001
https://academic.hep.com.cn/jtn/EN/Y2022/V7/I1/1

[1]	Zhilan Yang, Hongying Pan, Lan Jiang, Tiantian Jiang, Jie Wu. Research progress of hsa-miR-495-3p and proteolipid protein 1 involvement in the pathogenesis of schizophrenia[J]. Journal of Translational Neuroscience, 2022, 7(1): 11-14.
[2]	Zhilan Yang, Hongying Pan, Lan Jiang, Tiankai Jiang, Yinhang Li, Jie Wu. Research progress on the mechanism of N6-methyladenosine methylation modification and proteolipid protein 1 gene in schizophrenia[J]. Journal of Translational Neuroscience, 2022, 7(1): 6-10.

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