|
|
|
Microglia subtypes in Alzheimer's disease: insights from single-cell omics |
| Ruikang Han1,2, Feng Li3* |
1.School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China
2.School of Stomatology, Capital Medical University, Beijing 100050, China
3.Department of Neurobiology, Capital Medical University, Beijing 100069, China |
|
|
|
|
Abstract Microglia are immune-competent cells involved in maintaining brain homeostasis through their capacity to prune synapses and continuously survey the brain environment. The activation of microglia is one of the most prominent characteristics of Alzheimer’s disease (AD), a severe neurodegenerative disease featuring extracellular deposits of amyloid-β plaques (Aβ plaques) and intracellular neurofibrillary tangles (NFTs) as the result of tau hyperphosphorylation. Whether microglia activation is beneficial or detrimental for brains with AD is still controversial. In this article, we review recent studies focusing on microglia phenotypes in AD by single-cell omics, to understand the signature genes, functions, and regulatory factors of each phenotype. A profound understanding of the heterogeneity of microglial phenotypes will suggest new avenues for treatments for AD.
|
| Keywords
microglia
Alzheimer’s disease
immunity
subtype
heterogeneity
neuroinflammation
lipid metabolism
|
|
Issue Date: 25 December 2024
|
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
