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PF4 and CXCL5 as potential diagnostic biomarkers and therapeutic targets for Parkinson’s disease complicated by ulcerative colitis |
| Jie Li1#, Weiwei Yang2#, Ming Zhou2, Shengli Xu2,3* |
1.Department of Neurology, Beijing Daxing District Hospital of Integrated Chinese and Western Medicine, Beijing 100076, China
2.Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing 100053, China
3.Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Dis- ease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China |
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Abstract While accumulating evidence indicates a relationship between ulcerative colitis (UC) and Parkinson’s disease (PD), the interactions between them have not been thoroughly examined. In this study we explored their association via genetic characterization and functional enrichment. Assessment and validation were conducted in a novel dataset comprising whole blood RNA sequencing (RNAseq) data and in three datasets retrieved from the Gene Expression Omnibus database (GSE107499, GSE75214, and GSE100054). Weighted gene co-expression network analysis was used to determine the most relevant differentially expressed genes (DEGs) for the clinical features. Hub genes were identified using molecular complex detection (MCODE) application. In the training and validation datasets, we found two hub genes platelet factor 4 (PF4) and C-X-C motif chemokine ligand 5 (CXCL5), which showed significant upregulation in all four datasets. The receiver operating characteristic curve indicated a diagnostic role for PF4 and CXCL5 in UC and PD. Therefore, PF4 and CXCL5 may provide key insights into the relationship between UC and PD.
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| Keywords
ulcerative colitis
Parkinson's disease
weighted gene co-expression network analysis
immune cell infiltration
hub gene
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Issue Date: 25 December 2024
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