Exploration of peripheral blood <i>ZSCAN12</i> mRNA expression levels in patients with first-episode schizophrenia

doi:10.3868/j.issn.2096-0689.2024.04.005

Journal of Translational Neuroscience

2024, Vol. 9

Issue (4) : 47-51 https://doi.org/10.3868/j.issn.2096-0689.2024.04.005

Research Article

Exploration of peripheral blood ZSCAN12 mRNA expression levels in patients with first-episode schizophrenia

Ran Tian, Chen Yu, Xudong Zhou, Zhilan Yang^*

Department of Clinical Psychology, The Affiliated Mental Hospital of Kunming Medical University, Kunming 650000, China

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Abstract Objective: To investigate the changes of mRNA expression level of zinc finger and SCAN domain containing 12 (ZSCAN12) in peripheral blood of first-episode schizophrenia (SCZ). Methods: For our study we selected 17 individuals who had a first episode of SCZ and were hospitalized in the Affiliated Mental Hospital of Kunming Medical University from January 2024 to June 2024; we measured the mRNA expression level of ZSCAN12 in peripheral lymphocytes by quantitative real-time polymerase chain reaction (Q-PCR) method in the study group and compared it to a control group consisting of 15 healthy patients. Results: There was no significant difference in the expression of ZSCAN12 mRNA in peripheral blood lymphocytes of SCZ patients and healthy controls (P > 0.05). Conclusion: The expression of ZSCAN12 mRNA was not significantly abnormal in SCZ patients in this study.

Keywords schizophrenia zinc finger and SCAN domain containing 12 peripheral lymphocytes

Issue Date: 25 December 2024

Cite this article:

Ran Tian, Chen Yu, Xudong Zhou, Zhilan Yang. Exploration of peripheral blood ZSCAN12 mRNA expression levels in patients with first-episode schizophrenia[J]. Journal of Translational Neuroscience,2024, 9(4): 47-51.

URL:

https://academic.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2024.04.005
https://academic.hep.com.cn/jtn/EN/Y2024/V9/I4/47

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