Journal of Translational Neuroscience(转化神经科学电子杂志)
Cover Story   2022, Volume 7 Issue 1
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, Volume 7 Issue 1

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Special Topic: Research Progress of Schizophrenia Related Genes
Research progress of the synapsin 2 gene polymorphism in the pathogenesis of schizophrenia
Zhilan Yang, Hongying Pan, Lan Jiang, Yuhang Liang, Jie Wu
Journal of Translational Neuroscience. 2022, 7 (1): 1-5.  
https://doi.org/10.3868/j.issn.2096-0689.2022.01.001

Abstract   PDF (6073KB)
Schizophrenia (SCZ) is the most common serious mental illness with a high disability rate and heavy social and family burdens. At present, there is no clear etiology and pathogenesis of schizophrenia. Studies have shown that the occurrence of schizophrenia may be related to the abnormality of the hypothalamic-pituitary-adrenal (HPA) axis. The LIM-homeobox gene 3 (LHX3) and early growth response 1 (EGR1) can affect pituitary function. Because the synapsin 2 (SYN2) gene polymorphism regulates the activity of LHX3 and EGR1, it may cause the occurrence of schizophrenia. This article will review the possible involvement of SYN2 gene polymorphism in the pathogenesis of schizophrenia via regulating the activity of LHX3 and EGR1, then to affect the HPA axis.
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Research progress on the mechanism of N6-methyladenosine methylation modification and proteolipid protein 1 gene in schizophrenia
Zhilan Yang, Hongying Pan, Lan Jiang, Tiankai Jiang, Yinhang Li, Jie Wu
Journal of Translational Neuroscience. 2022, 7 (1): 6-10.  
https://doi.org/10.3868/j.issn.2096-0689.2022.01.002

Abstract   PDF (5715KB)
Schizophrenia (SCZ) is a serious mental illness with unknown etiology, high recurrence rate and high disability rate, which has caused a great burden to individuals and society. There is no clear etiology and pathogenesis. Methylation of N6-methyladenosine (m6A) can regulate the nervous and mental system, and affect the function of the nervous system. Proteolipid protein 1 (PLP1) is a risk gene for schizophrenia. In this study we review the research progress on the pathogenesis of schizophrenia, m6A methylation, and PLP1 gene.
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Research progress of hsa-miR-495-3p and proteolipid protein 1 involvement in the pathogenesis of schizophrenia
Zhilan Yang, Hongying Pan, Lan Jiang, Tiantian Jiang, Jie Wu
Journal of Translational Neuroscience. 2022, 7 (1): 11-14.  
https://doi.org/10.3868/j.issn.2096-0689.2022.01.003

Abstract   PDF (4542KB)
Schizophrenia (SCZ) is a serious mental illness whose etiology and pathogenesis are not yet clear. The level of miRNA may be a crucial factor in the occurrence and development of SCZ. This study found that miR-495 may regulate the susceptibility gene of SCZ and that proteolipid protein 1 (PLP1) as a risk gene for schizophrenia may be involved in its pathogenesis. In this article we review the research progress related to hsa-miR-495-3p (miR-495), PLP1, and schizophrenia.
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Research Article
Bioinformatics analysis of genes differentially expressed in autism and screening of hub genes in the occurrence and development of autism
Manli Li, Xiaoli Ma, Chendi Mai, Zhiru Fan, Yankai Ren
Journal of Translational Neuroscience. 2022, 7 (1): 15-22.  
https://doi.org/10.3868/j.issn.2096-0689.2022.01.004

Abstract   PDF (8227KB)
Objective: to screen the genes differentially expressed in autism using bioinformatics methods, and to explore their functional enrichment, related signaling pathways and the tissue-specific expression of hub genes. Methods: the autism expression profile chip numbered GSE77103 in the Gene Expression Omnibus (GEO) database was selected for examination. R language and related R packages were used for the screening and visualization of the differentially expressed genes. Gene Ontology (GO) function enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway analysis of the differential genes were carried out using the relevant R package of R language. The database STRING was used to construct the interaction network of the proteins encoded by the differentially expressed genes, and the software Cytoscape was used to screen the hub genes in the network. The selected hub genes were imported into the BioGPS database to analyze the tissue-specific expression of the hub genes. Results: six hundred and sixty differentially expressed genes were screened out. Three hundred and seventy-three up-regulated genes and 287 down-regulated genes in the peripheral blood mononuclear cells of autistic children were compared with the peripheral blood mononuclear cells of healthy children. GO functional enrichment results showed that biological processes (BP) were mainly involved in viral response, negative regulation of viral genome replication, negative regulation of multiple biological processes, negative regulation of viral life cycle, and defense responses to viruses. Cell components (CC) were involved in vesicles, lysosomal membranes, lysosomal lumen, etc.; molecular functions (MF) were involved in regulating glutathione transferase activity, peroxidase activity, oxidoreductase activity, Glutathione peroxidase and transferase activity, etc. The results of KEGG signaling pathway analysis showed that the differentially expressed genes were related to the lysosomal pathway, the glutathione metabolism pathway and the arachidonic acid metabolism pathway. The hub genes screened by cytoHubba were: interferon regulatory factor 7 (IRF7), interferon stimulated exonuclease gene 15 (ISG15), XIAP associated factor 1 (XAF1), MX dynamin like GTPase 1 (MX1), interferon induced protein with tetratricopeptide repeats 1 (IFIT1), interferon induced protein with tetratricopeptide repeats 5 (IFIT5), 2’-5’-oligoadenylate synthetase 3 (OAS3), interferon induced protein 44 (IFI44), HECT and the RLD domain containing E3 ubiquitin protein ligase 5 (HERC5), interferon stimulated exonuclease gene 20 (ISG20). Conclusion: there are genes that are differentially expressed in the peripheral blood mononuclear cells of autistic toddlers and healthy toddlers. IRF7, ISG15, XAF1, MX1, IFIT1, IFIT5, OAS3, IFI44, HERC5, ISG20 are the hub regulatory genes of autism.
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Case Report
Bronchial cyst of the posterior mediastinum misdiagnosed as ganglioneuroma: a case report and literature review
Yi Bao, Qiong Liu, Hang Li, Wei Huang, Zhibing Ai
Journal of Translational Neuroscience. 2022, 7 (1): 23-26.  
https://doi.org/10.3868/j.issn.2096-0689.2022.01.005

Abstract   PDF (5204KB)
Objective: to investigate the clinical and pathological characteristics of bronchial cyst of the posterior mediastinum misdiagnosed as a ganglioneuroma, and to improve the level of their diagnosis, differential diagnosis, and treatment. Methods: the clinical data and pathological findings of a young woman misdiagnosed with a ganglioneuroma was collected and analyzed, and the relevant literature were reviewed. Results: the patient had no specific clinical symptoms. The right posterior mediastinum was accidentally found due to a physical examination for COVID-19. The enhanced chest computed tomography (CT) showed a ganglioneuroma. After a thoracoscopic resection of the lesion, a pathological diagnosis revealed a posterior mediastinal bronchial cyst. Conclusion: bronchial cyst of the mediastinum is rare and their clinical symptoms are atypical and can be easily diagnosed as a ganglioneuroma. It can be preliminarily judged by laboratory and imaging examination and confirmed by pathological examination. The main treatment is surgical resection.
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5 articles