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Protein & Cell

ISSN 1674-800X

ISSN 1674-8018(Online)

CN 11-5886/Q

邮发代号 80-984

2019 Impact Factor: 10.164

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Protein & Cell  2010, Vol. 1 Issue (10): 916-926   https://doi.org/10.1007/s13238-010-0116-9
  REVIEW 本期目录
microRNAs: tiny RNA molecules, huge driving forces to move the cell
microRNAs: tiny RNA molecules, huge driving forces to move the cell
Shenglin Huang, Xianghuo He()
State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China
 全文: PDF(345 KB)   HTML
Abstract：

Cell migration or movement is a highly dynamic cellular process, requiring precise regulation that is essential for a variety of biological processes. microRNAs (miRNAs) are a class of tiny non-coding RNA molecules that function as critical post-transcriptional regulators of gene expression. Emerging evidence demonstrates that miRNAs play important roles in cell migration and directly contribute to extracellular matrix (ECM) remodeling, cell adhesion, and cell signalling that controls cell migration by targeting a large number of protein-coding genes. Accordingly, the dysregulation of these miRNAs has been linked to several migration-related diseases. In this review, we summarize and highlight the recent advances concerning the roles and validated targets of miRNAs in the control of cell movement.
Key words： microRNA    cell migration    metastasis
收稿日期: 2010-09-20      出版日期: 2010-10-01
Corresponding Author(s): He Xianghuo,Email:xhhe@shsci.org   
 引用本文:   
. microRNAs: tiny RNA molecules, huge driving forces to move the cell[J]. Protein & Cell, 2010, 1(10): 916-926.
Shenglin Huang, Xianghuo He. microRNAs: tiny RNA molecules, huge driving forces to move the cell. Prot Cell, 2010, 1(10): 916-926.
 链接本文:  
https://academic.hep.com.cn/pac/CN/10.1007/s13238-010-0116-9
https://academic.hep.com.cn/pac/CN/Y2010/V1/I10/916
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miRNAregulationtargetsmigrationfunctionreferences
Let-7--COL1A2--inhibits HCC cell migrationJi et al., 2010
miR-1/206--c-Met--inhibits rhabdomyosarcoma developmentYan et al., 2009
miR-10btwistHOXD10, Tiam1, Rac1, KLF4+promotes cell migration and invasiveness in breast cancer, glioma, and squamous cell carcinoma cellsMa et al., 2007; Tian et al., 2010
miR-101--FOS--Inhibits HCC cell invasionLi et al., 2009b
miR-122--ADAM10, ADAM17--inhibits HCC cell migration and metastasisBai et al., 2009; Tsai et al., 2009
miR-125EGFR regulatedErbB2/3--inhibits cell migration and invasion in breast cancer and lung cancer cellsScott et al., 2007; Wang et al., 2009
miR-126--Crk--inhibits lung cancer cell migration and invasionCrawford et al., 2008
miR-128--Reelin, DCX--inhibits neuroblastoma cell motility and invasivenessEvangelisti et al., 2009
miR-138--RhoC, ROCK2--inhibits tongue squamous cell carcinoma cell migration and invasionJiang et al., 2010
miR-143NF-κB, myocardinVersican, FNDC3B--inhibits smooth muscle cells migrationWang et al., 2010b; Zhang et al., 2009
miR-146BRMS1EGFR, MMP16, ROCK1--inhibits cell migration and invasion in breast cancer and glioma cellsLin et al., 2008; Xia et al., 2009
miR-150--C-myb+promotes endothelial cell migrationZhang et al., 2010
miR-151amplificationRhoGDIA+promotes HCC cell migration and metastasisDing et al., 2010
miR-17/20c-mycIL-8, CXCL1, CK8, fibronectin, FNDC3A--inhibits breast cancer cell migration and metastasisShan et al., 2009; Yu et al., 2010
miR-181bTGF-βTIMP3+promotes HCC cell migration and invasionWang et al., 2010a
miR-182amplificationFOXO3, Mitf-M+promotes melanoma cell migration and metastasisSegura et al., 2009
miR-183Integrin 1, kinesin 2, ezrin--inhibits cell migration and invasion in HeLa and lung cancer cellsWang et al., 2008b; Li et al., 2010
miR-196BMP4, Pax7--inhibits tail regeneration of salamandersSehm et al., 2009
miR-199a-3pmTOR, c-Met--inhibits HCC cell invasionFornari et al., 2010
miR-200ZEB1, ZEB2--counteracts epithelial-to-mesenchymal transition and reduces cell migration/invasionKorpal et al., 2008
miR-205LRP1--inhibits cell migration and invasionSong and Bu, 2009
miR-21TIMP3, RECK, PTEN+promotes cell migration and invasion in breast cancer, glima, and HCC cellsMeng et al., 2007; Gabriely et al., 2008
miR-210HIF-1Ephrin-A3+promotes endothelial cell migration in response to hypoxiaFasanaro et al., 2008
miR-221c-junPTEN, TIMP3, DDIT4, c-kit±promotes migration and metastasis in NSCLC and HCC cells. Inhibits vascular smooth muscle cells migrationGarofalo et al., 2009; Li et al., 2009c; Pineau et al., 2010; Poliseno et al., 2006
miR-23b--uPA, c-Met--inhibits HCC cell migration and invasionSalvi et al., 2009
miR-27b--Pax3--regulates myogenic differentiation and inhibits muscle stem cell migrationCrist et al., 2009
miR-29c--Collagens, laminin 1,--inhibits nasopharyngeal carcinomas cell migration and metastasisSengupta et al., 2008
miR-30d--Gnail2+promotes HCC cell migration and metastasisYao et al., 2010
miR-31--MMP16, RhoA--inhibits cell migration and metastasis in breast cancer cellsValastyan et al., 2009
miR-328--CD44+regulates zonation morphogenesisWang et al., 2008a
miR-335--SOX4, tenascin C--inhibits breast cancer cell migration and metastasisTavazoie et al., 2008
miR-34a--c-Met--inhibits HCC cell migration and invasionLi et al., 2009a
miR-373/520--CD44+promotes breast cancer cell migration and metastasisHuang et al., 2008
miR-661c/EBPAMTA1--inhibits breast cancer cell migration and invasionReddy et al., 2009
miR-7HoxD10PAK1--inhibits breast cancer cell migration and invasionReddy et al., 2008
miR-9MYC/MYCNE-cadherin, stathmin±promotes breast cancer cell migration and metastasis. Inhibits human neural progenitor cells migrationDelaloy et al., 2010; Ma et al., 2010
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