Regulation of developmental and environmental signaling by interaction between microtubules and membranes in plant cells

doi:10.1007/s13238-015-0233-6

Protein & Cell

2016, Vol. 7

Issue (2): 81-88 https://doi.org/10.1007/s13238-015-0233-6

本期目录

Regulation of developmental and environmental signaling by interaction between microtubules and membranes in plant cells

Qun Zhang(

),Wenhua Zhang(

)

College of Life Sciences, State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China

全文: PDF(1067 KB)

Abstract：

Cell division and expansion require the ordered arrangement of microtubules, which are subject to spatial and temporal modifications by developmental and environmental factors. Understanding how signals translate to changes in cortical microtubule organization is of fundamental importance. A defining feature of the cortical microtubule array is its association with the plasma membrane; modules of the plasma membrane are thought to play important roles in the mediation of microtubule organization. In this review, we highlight advances in research on the regulation of cortical microtubule organization by membrane-associated and membrane-tethered proteins and lipids in response to phytohormones and stress. The transmembrane kinase receptor Rho-like guanosine triphosphatase, phospholipase D, phosphatidic acid, and phosphoinositides are discussed with a focus on their roles in microtubule organization.

Key words： abiotic stresses cortical microtubule lipids plasma membrane

收稿日期: 2015-08-31 出版日期: 2016-04-13

Corresponding Author(s): Qun Zhang,Wenhua Zhang

引用本文:

. [J]. Protein & Cell, 2016, 7(2): 81-88.
Qun Zhang,Wenhua Zhang. Regulation of developmental and environmental signaling by interaction between microtubules and membranes in plant cells. Protein Cell, 2016, 7(2): 81-88.

链接本文:

https://academic.hep.com.cn/pac/CN/10.1007/s13238-015-0233-6
https://academic.hep.com.cn/pac/CN/Y2016/V7/I2/81

1	Achard P, Cheng H, De Grauwe L, Decat J, Schoutteten H, Moritz T, Van Der Straeten D, Peng J, Harberd NP (2006) Integration of plant responses to environmentally activated phytohormonal signals. Science 311:91–94 https://doi.org/10.1126/science.1118642
2	Adamowski M, Friml J (2015) PIN-dependent auxin transport: action, regulation, and evolution. Plant Cell 27:20–32 https://doi.org/10.1105/tpc.114.134874
3	Ambrose JC, Wasteneys GO (2008) CLASP modulates microtubulecortex interaction during self-organization of acentrosomal microtubules. Mol Biol Cell 19:4730–4737 https://doi.org/10.1091/mbc.E08-06-0665
4	Ambrose C, Ruan Y, Gardiner J, Tamblyn LM, Catching A, Kirik V,Marc J, Overall R, Wasteneys GO (2013) CLASP interacts with sorting nexin 1 to link microtubules and auxin transport via PIN2 recycling in Arabidopsis thaliana. Dev Cell 24:649–659 https://doi.org/10.1016/j.devcel.2013.02.007
5	Barton DA, Vantard M, Overall RL (2008) Analysis of cortical arrays from Tradescantia virginiana at high resolution reveals discrete microtubule subpopulations and demonstrates that confocal images of arrays can be misleading. Plant Cell 20:982–994 https://doi.org/10.1105/tpc.108.058503
6	Baster P, Robert S, Kleine-Vehn J, Vanneste S, Kania U, Grunewald W, De Rybel B, Beeckman T, Friml J (2013) SCF(TIR1/AFB)-auxin signalling regulates PIN vacuolar trafficking and auxin fluxes during root gravitropism. EMBO J 32:260–274 https://doi.org/10.1038/emboj.2012.310
7	Beck M, Komis G, Ziemann A, Menzel D, Samaj J (2011) Mitogenactivated protein kinase 4 is involved in the regulation of mitoticand cytokinetic microtubule transitions in Arabidopsis thaliana. New Phytol 189:1069–1083 https://doi.org/10.1111/j.1469-8137.2010.03565.x
8	Boutte Y, Crosnier MT, Carraro N, Traas J, Satiat-Jeunemaitre B(2006) The plasma membrane recycling pathway and cell polarityin plants: studies on PIN proteins. J Cell Sci 119:1255–1265 https://doi.org/10.1242/jcs.02847
9	Brandizzi F, Wasteneys GO (2013) Cytoskeleton-dependent endomembrane organization in plant cells: an emerging role for microtubules. Plant J 75:339–349 https://doi.org/10.1111/tpj.12227
10	Cao L, Wang L, Zheng M, Cao H, Ding L, Zhang X, Fu Y (2013) Arabidopsis AUGMIN subunit8 is a microtubule plus-end binding protein that promotes microtubule reorientation in hypocotyls. Plant Cell 25:2187–2201 https://doi.org/10.1105/tpc.113.113472
11	Chen X, Grandont L, Li H, Hauschild R, Paque S, Abuzeineh A, Rakusova H, Benkova E, Perrot-Rechenmann C, Friml J (2014) Inhibition of cell expansion by rapid ABP1-mediated auxin effect on microtubules. Nature 516:90–93 https://doi.org/10.1038/nature13889
12	Deeks MJ, Fendrych M, Smertenko A, Bell KS, Oparka K, Cvrckova F, Zarsky V,Hussey PJ (2010) The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain. J Cell Sci 123:1209–1215 https://doi.org/10.1242/jcs.065557
13	Dhonukshe P, Laxalt AM, Goedhart J, Gadella TW, Munnik T (2003) Phospholipase D activation correlates with microtubule reorganization in living plant cells. Plant Cell 15:2666–2679 https://doi.org/10.1105/tpc.014977
14	Dixit R, Cyr R (2004) The cortical microtubule array: from dynamics to organization. Plant Cell 16:2546–2552 https://doi.org/10.1105/tpc.104.161030
15	Effendi Y, Jones AM, Scherer GF (2013) AUXIN-BINDING-PROTEIN1(ABP1) in phytochrome-B-controlled responses. J Exp Bot 64:5065–5074 https://doi.org/10.1093/jxb/ert294
16	Ehrhardt DW, Shaw SL (2006) Microtubule dynamics and organizationin the plant cortical array. Annu Rev Plant Biol 57:859–875 https://doi.org/10.1146/annurev.arplant.57.032905.105329
17	Eisinger W, Ehrhardt D, Briggs W (2012a) Microtubules are essential for guard-cell function in Vicia and Arabidopsis. Mol Plant 5:601–610 https://doi.org/10.1093/mp/sss002
18	Eisinger WR, Kirik V, Lewis C, Ehrhardt DW, Briggs WR (2012b) Quantitative changes in microtubule distribution correlate with guard cell function in Arabidopsis. Mol Plant 5:716–725 https://doi.org/10.1093/mp/sss033
19	Enders TA, Oh S, Yang Z, Montgomery BL, Strader LC (2015) Genome sequencing of Arabidopsis abp1-5 reveals second-site mutations that may affect phenotypes. Plant Cell 27:1820–1826 https://doi.org/10.1105/tpc.15.00214
20	Galatis B, Apostolakos P (2004) The role of the cytoskeleton in the morphogenesis and function of stomatal complexes. New Phytol 161:613–639 https://doi.org/10.1046/j.1469-8137.2003.00986.x
21	Gao Y, Zhang Y, Zhang D, Dai X, Estelle M, Zhao Y (2015) Auxin binding protein 1 (ABP1) is not required for either auxin signaling or Arabidopsis development. Proc Natl Acad Sci U S A 112:2275–2280 https://doi.org/10.1073/pnas.1500365112
22	Gardiner JC, Harper JD, Weerakoon ND, Collings DA, Ritchie S, Gilroy S, Cyr RJ, Marc J(2001) A 90-kD phospholipase D from tobacco binds to microtubules and the plasma membrane. Plant Cell 13:2143–2158 https://doi.org/10.1105/tpc.13.9.2143
23	Geldner N, Friml J, Stierhof YD, Jurgens G, Palme K(2001) Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. Nature 413:425–428 https://doi.org/10.1038/35096571
24	Gu Y, Deng Z, Paredez AR, DeBolt S, Wang ZY, Somerville C (2008) Prefoldin 6 is required for normal microtubule dynamics and organization in Arabidopsis. Proc Natl Acad Sci USA 105:18064–18069 https://doi.org/10.1073/pnas.0808652105
25	Gudesblat GE, Russinova E (2011) Plants grow on brassinosteroids. Curr Opin Plant Biol 14:530–537 https://doi.org/10.1016/j.pbi.2011.05.004
26	Hamada T (2014) Microtubule organization and microtubule-associated proteins in plant cells. Int Rev Cell Mol Biol 312:1–52 https://doi.org/10.1016/B978-0-12-800178-3.00001-4
27	Hashimoto T (2015) Microtubules in plants. Arabidopsis Book 13:e0179 https://doi.org/10.1199/tab.0179
28	Heisler MG, Hamant O, Krupinski P, Uyttewaal M, Ohno C, Jönsson H, Traas J, Meyerowitz EM (2010) Alignment between PIN1 polarity and microtubule orientation in the shoot apical meristem reveals a tight coupling between morphogenesis and auxint ransport. PLoS Biol 8:e1000516 https://doi.org/10.1371/journal.pbio.1000516
29	Ho AY, Day DA, Brown MH, Marc J (2009) Arabidopsis phospho lipaseD δ as an initiator of cytoskeleton-mediated signalling to fundamental cellular processes. Funct Plant Biol 36:190–198 https://doi.org/10.1071/FP08222
30	Huang S, Blanchoin L, Kovar DR, Staiger CJ (2003) Arabidopsis capping protein (AtCP) is a heterodimer that regulates assembly at the barbed ends of actin filaments. J Biol Chem 278:44832–44842 https://doi.org/10.1074/jbc.M306670200
31	Huang S, Gao L, Blanchoin L, Staiger CJ (2006) Heterodimeric capping protein from Arabidopsis is regulated by phosphatidic acid. Mol Biol Cell 17:1946–1958 https://doi.org/10.1091/mbc.E05-09-0840
32	Jiang Y, Wu K, Lin F, Qu Y, Liu X, Zhang Q (2014) Phosphatidic acid integrates calcium signaling and microtubule dynamics into regulating ABA-induced stomatal closure in Arabidopsis. Planta 239:565–575 https://doi.org/10.1007/s00425-013-1999-5
33	Kato M, Nagasaki-Takeuchi N, Ide Y, Maeshima M (2010) An Arabidopsis hydrophilic Ca2+ -binding protein with a PEVK-rich domain, PCaP2, is associated with the plasma membrane and interacts with calmodulin and phosphatidylinositol phosphates. Plant Cell Physiol 51:366–379 https://doi.org/10.1093/pcp/pcq003
34	Keerthisinghe S, Nadeau JA, Lucas JR, Nakagawa T, Sack FD (2015) The Arabidopsis leucine-rich repeat receptor-like kinase MUSTACHES enforces stomatal bilateral symmetry in Arabidopsis. Plant J 81:684–694 https://doi.org/10.1111/tpj.12757
35	Kendrick MD, Chang C (2008) Ethylene signaling: new levels of complexity and regulation. Curr Opin Plant Biol 11:479–485 https://doi.org/10.1016/j.pbi.2008.06.011
36	Khanna R, Li J, Tseng TS, Schroeder JI, Ehrhardt DW, Briggs WR (2014) COP1 jointly modulates cytoskeletal processes and electrophysiological responses required for stomatal closure. Mol Plant 7:1441–1454 https://doi.org/10.1093/mp/ssu065
37	Kleine-Vehn J, Langowski L, Wisniewska J, Dhonukshe P, Brewer PB, Friml J (2008) Cellular and molecular requirements for polar PIN targeting and transcytosis in plants. Mol Plant 1:1056–1066 https://doi.org/10.1093/mp/ssn062
38	Li J (2010) Regulation of the nuclear activities of brassinosteroid signaling. Curr Opin Plant Biol 13:540–547 https://doi.org/10.1016/j.pbi.2010.08.007
39	Li J, Wang X, Qin T, Zhang Y, Liu X, Sun J, Zhou Y, Zhu L, Zhang Z, Yuan M, Mao T (2011) MDP25, a novel calcium regulatory protein, mediates hypocotyl cell elongation by destabilizing cortical microtubules in Arabidopsis. Plant Cell 23:4411–4427 https://doi.org/10.1105/tpc.111.092684
40	Li J, Henty-Ridilla JL, Huang S, Wang X, Blanchoin L, Staiger CJ (2012) Capping protein modulates the dynamic behavior of actin filaments in response to phosphatidic acid in Arabidopsis. Plant Cell 24:3742–3754 https://doi.org/10.1105/tpc.112.103945
41	Lin D, Cao L, Zhou Z, Zhu L, Ehrhardt D, Yang Z, Fu Y (2013) Rho GTPase signaling activates microtubule severing to promote microtubule ordering in Arabidopsis. Curr Biol 23:290–297 https://doi.org/10.1016/j.cub.2013.01.022
42	Lin F, Qu Y, Zhang Q (2014) Phospholipids: molecules regulating cytoskeletal organization in plant abiotic stress tolerance. Plant Signal Behav 9:e28337 https://doi.org/10.4161/psb.28337
43	Lindeboom JJ, Nakamura M, Hibbel A, Shundyak K, Gutierrez R,Ketelaar T, Emons AM, Mulder BM, Kirik V, Ehrhardt DW (2013) A mechanism for reorientation of cortical microtubule arrays driven by microtubule severing. Science 342:1245533 https://doi.org/10.1126/science.1245533
44	Liu CM (2015) AUXIN BINDING PROTEIN 1 (ABP1): a matter of fact. J Integr Plant Biol 57:234–235 https://doi.org/10.1111/jipb.12339
45	Liu X, Qin T, Ma Q, Sun J, Liu Z, Yuan M, Mao T (2013) Lightregulated hypocotyl elongation involves proteasome-dependent degradation of the microtubule regulatory protein WDL3 in Arabidopsis. Plant Cell 25:1740–1755 https://doi.org/10.1105/tpc.113.112789
46	Lloyd C, Chan J (2004) Microtubules and the shape of plants to come. Nat Rev Mol Cell Biol 5:13–22 https://doi.org/10.1038/nrm1277
47	Locascio A, Blazquez MA, Alabadi D (2013) Dynamic regulation of cortical microtubule organization through prefoldin-DELLA interaction. Curr Biol 23:804–809 https://doi.org/10.1016/j.cub.2013.03.053
48	Lucas J, Shaw SL (2008) Cortical microtubule arrays in the Arabidopsis seedling. Curr Opin Plant Biol 11:94–98 https://doi.org/10.1016/j.pbi.2007.12.001
49	Lucas JR, Nadeau JA, Sack FD (2006) Microtubule arrays and Arabidopsis stomatal development. J Exp Bot 57:71–79 https://doi.org/10.1093/jxb/erj017
50	Mao J, Zhang YC, Sang Y, Li QH, Yang HQ (2005) From The Cover:A role for Arabidopsis cryptochromes and COP1 in the regulation of stomatal opening. Proc Natl Acad Sci U S A 102:12270–12275 https://doi.org/10.1073/pnas.0501011102
51	Marcus AI, Moore RC, Cyr RJ (2001) The role of microtubules in guard cell function. Plant Physiol 125:387–395 https://doi.org/10.1104/pp.125.1.387
52	Mollinari C, Kleman JP, Jiang W, Schoehn G, Hunter T, Margolis RL (2002) PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol 157:1175–1186 https://doi.org/10.1083/jcb.200111052
53	Muller M, Munne-Bosch S (2015) Ethylene response fekerehub in hormone and stress signaling. Plant Physiol 169:32–41 https://doi.org/10.1104/pp.15.00677
54	Nagasaki N, Tomioka R, Maeshima M (2008) A hydrophilic cationbinding protein of Arabidopsis thaliana, AtPCaP1, is localized to plasma membrane via N-myristoylation and interacts with calmodulin and the phosphatidylinositol phosphates PtdIns (3,4,5) P3 and PtdIns (3,5) P2. FEBS J 275:2267–2282 https://doi.org/10.1111/j.1742-4658.2008.06379.x
55	Nakajima K, Furutani I, Tachimoto H, Matsubara H, Hashimoto T (2004) SPIRAL1 encodes a plant-specific microtubule-localized protein required for directional control of rapidly expanding Arabidopsis cells. Plant Cell 16:1178–1190 https://doi.org/10.1105/tpc.017830
56	Oda Y, Fukuda H (2012) Initiation of cell wall pattern by a Rho- and microtubule-driven symmetry breaking. Science 337:1333–1336 https://doi.org/10.1126/science.1222597
57	Oda Y, Fukuda H (2013) The dynamic interplay of plasma membrane domains and cortical microtubules in secondary cell wall patterning. Front Plant Sci 4:1–6 https://doi.org/10.3389/fpls.2013.00511
58	Paque S, Mouille G, Grandont L, Alabadi D, Gaertner C, Goyallon A, Muller P, Primard-Brisset C, Sormani R, Blazquez MA, Perrot-Rechenmann C (2014) AUXIN BINDING PROTEIN1 links cell wall remodeling, auxin signaling, and cell expansion in Arabidopsis. Plant Cell 26:280–295 https://doi.org/10.1105/tpc.113.120048
59	Peng J, Richards DE, Hartley NM, Murphy GP, Devos KM, Flintham JE, Beales J, Fish LJ, Worland AJ, Pelica F et al (1999) ‘Green revolution’ genes encode mutant gibberellin response modulators. Nature 400:256–261 https://doi.org/10.1038/22307
60	Pleskot R, Potocky M, Pejchar P, Linek J, Bezvoda R, Martinec J, Valentova O, Novotna Z,Zarsky V (2010) Mutual regulation of plant phospholipase D and the actin cytoskeleton. Plant J 62:494–507 https://doi.org/10.1111/j.1365-313X.2010.04168.x
61	Pleskot R, Li J, Zarsky V, Potocky M, Staiger CJ (2013) Regulation of cytoskeletal dynamics by phospholipase D and phosphatidic acid. Trends Plant Sci 18:496–504 https://doi.org/10.1016/j.tplants.2013.04.005
62	Pleskot R, Pejchar P, Staiger CJ, Potocky M (2014) When fat is not bad: the regulation of actin dynamics by phospholipid signaling molecules. Front Plant Sci 5:1–6 https://doi.org/10.3389/fpls.2014.00005
63	Polko JK, van Zanten M, van Rooij JA, Maree AF, Voesenek LA, Peeters AJ, Pierik R (2012) Ethylene-induced differential petiole growth in Arabidopsis thaliana involves local microtubule reorientation and cell expansion. New Phytol 193:339–348 https://doi.org/10.1111/j.1469-8137.2011.03920.x
64	Robert S, Kleine-Vehn J, Barbez E, Sauer M, Paciorek T, Baster P, Vanneste S, Zhang J, Simon S, Covanova M, Hayashi K,Dhonukshe P, Yang Z, Bednarek SY, Jones AM, Luschnig C,Aniento F, Zazimalova E, Friml J (2010) ABP1 mediates auxin inhibition of clathrin-dependent endocytosis in Arabidopsis. Cell 143:111–121 https://doi.org/10.1016/j.cell.2010.09.027
65	Rodriguez-Milla MA, Salinas J (2009) Prefoldins 3 and 5 play an essential role in Arabidopsis tolerance to salt stress. Mol Plant 2:526–534 https://doi.org/10.1093/mp/ssp016
66	Ruan Y, Wasteneys GO (2014) CLASP: a microtubule-based integrator of the hormone-mediated transitions from cell division to elongation. Curr Opin Plant Biol 22:149–158 https://doi.org/10.1016/j.pbi.2014.11.003
67	Sambade A, Pratap A, Buschmann H, Morris RJ, Lloyd C (2012) The influence of light on microtubule dynamics and alignment in the Arabidopsis hypocotyl. Plant Cell 24:192–201 https://doi.org/10.1105/tpc.111.093849
68	Sasabe M, Soyano T, Takahashi Y, Sonobe S, Igarashi H, Itoh TJ, Hidaka M, Machida Y (2006) Phosphorylation of NtMAP65-1 by a MAP kinase down-regulates its activity of microtubule bundling and stimulates progression of cytokinesis of tobacco cells. Genes Dev 20:1004–1014 https://doi.org/10.1101/gad.1408106
69	Sedbrook JC, Ehrhardt DW, Fisher SE, Scheible WR, Somerville CR (2004) The Arabidopsis sku6/spiral1 gene encodes a plus endlocalized microtubule-interacting protein involved in directional cell expansion. Plant Cell 16:1506–1520 https://doi.org/10.1105/tpc.020644
70	Shoji T, Suzuki K, Abe T, Kaneko Y, Shi H, Zhu JK, Rus A, Hasegawa PM, Hashimoto T (2006) Salt stress affects cortical microtubule organization and helical growth in Arabidopsis. Plant Cell Physiol 47:1158–1168 https://doi.org/10.1093/pcp/pcj090
71	Smertenko AP, Chang HY, Sonobe S, Fenyk SI, Weingartner M, Bogre L, Hussey PJ (2006) Control of the AtMAP65-1 interaction with microtubules through the cell cycle. J Cell Sci 119:3227–3237 https://doi.org/10.1242/jcs.03051
72	Stace CL, Ktistakis NT (2006) Phosphatidic acid- and phosphatidylserine-binding proteins. Biochim Biophys Acta 1761:913–926 https://doi.org/10.1016/j.bbalip.2006.03.006
73	Sun J, Ma Q, Mao T (2015) Ethylene regulates Arabidopsis microtubule-associated protein WDL5 in etiolated hypocotyl elongation. Plant Physiol 169:325–337 https://doi.org/10.1104/pp.15.00609
74	Takahashi H, Kawahara A, Inoue Y (2003) Ethylene promotes the induction by auxin of the cortical microtubule randomization required for low-pH-induced root hair initiation in lettuce (Lactuca sativa L.) seedlings. Plant Cell Physiol 44:932–940 https://doi.org/10.1093/pcp/pcg119
75	Wang C, Li J, Yuan M (2007) Salt tolerance requires cortical microtubule reorganization in Arabidopsis. Plant Cell Physiol 48:1534–1547 https://doi.org/10.1093/pcp/pcm123
76	Wang S, Kurepa J, Hashimoto T, Smalle JA (2011) Salt stressinduced disassembly of Arabidopsis cortical microtubule arrays involves 26S proteasome-dependent degradation of SPIRAL1. Plant Cell 23:3412–3427 https://doi.org/10.1105/tpc.111.089920
77	Wang X, Zhang J, Yuan M, Ehrhardt DW, Wang Z, Mao T (2012) Arabidopsis microtubule destabilizing protein 40 is involved in brassinosteroid regulation of hypocotyl elongation. Plant Cell 24:4012–4025 https://doi.org/10.1105/tpc.112.103838
78	Wang X, Guo L, Wang G, Li M (2014) PLD: phospholipase Ds in plant signaling. Springer, Berlin, pp 3–26 https://doi.org/10.1007/978-3-642-42011-5_1
79	Xu T, Dai N, Chen J, Nagawa S, Cao M, Li H, Zhou Z, Chen X, De Rycke R, Rakusová H (2014) Cell surface ABP1-TMK auxinsensing complex activates ROP GTPase signaling. Science 343:1025–1028 https://doi.org/10.1126/science.1245125
80	Ye J, Zhang W, Guo Y (2013) Arabidopsis SOS3 plays an important role in salt tolerance by mediating calcium-dependent microfilament reorganization. Plant Cell Rep 32:139–148 https://doi.org/10.1007/s00299-012-1348-3
81	Yu L, Nie J, Cao C, Jin Y, Yan M, Wang F, Liu J,Xiao Y, Liang Y, Zhang W (2010) Phosphatidic acid mediates salt stress response by regulation of MPK6 in Arabidopsis thaliana. New Phytol 188:762–773 https://doi.org/10.1111/j.1469-8137.2010.03422.x
82	Zhang Y, Zhu H, Zhang Q, Li M, Yan M, Wang R, Wang L, Welti R, Zhang W, Wang X(2009) Phospholipase Dalpha1 and phosphatidic acid regulate NADPH oxidase activity and production of reactive oxygen species in ABA-mediated stomatal closure in Arabidopsis. Plant Cell 21:2357–2377 https://doi.org/10.1105/tpc.108.062992
83	Zhang Q, Lin F, Mao T, Nie J, Yan M, Yuan M, Zhang W (2012) Phosphatidic acid regulates microtubule organization by interacting with MAP65-1 in response to salt stress in Arabidopsis. Plant Cell 24:4555–4576 https://doi.org/10.1105/tpc.112.104182
84	Zhang C, Raikhel NV, Hicks GR (2013) CLASPing microtubules and auxin transport. Dev Cell 24:569–571 https://doi.org/10.1016/j.devcel.2013.03.008

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