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Chemotaxis: new role for Ras revealed |
Jianshe Yan1( ), Dale Hereld2, Tian Jin1 |
| 1. Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA; 2. Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, NIH, 5635 Fishers Lane, Rockville, MD 20852, USA |
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Corresponding Author(s):
Yan Jianshe,Email:yanjia@niaid.nih.gov
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Issue Date: 01 October 2010
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| 1 |
Cai, H., Das, S., Kamimura, Y., Long, Y., Parent, C.A., and Devreotes, P.N. (2010). Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. J Cell Biol 190, 233–245 .
doi: 10.1083/jcb.201001129
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| 2 |
Charest, P.G., Shen, Z., Lakoduk, A., Sasaki, A.T., Briggs, S.P., and Firtel, R.A. (2010). A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev Cell 18, 737–749 .
doi: 10.1016/j.devcel.2010.03.017
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Chen, L., Iijima, M., Tang, M., Landree, M.A., Huang, Y.E., Xiong, Y., Iglesias, P.A., and Devreotes, P.N. (2007). PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell 12, 603–614 .
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Jin T, Xu X, Fang J, Isik N, Yan J, Brzostowski JA, Hereld D. (2009). How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum. Immunol Res 43, 118–27 .
doi: 10.1007/s12026-008-8056-7
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Kamimura, Y., Xiong, Y., Iglesias, P.A., Hoeller, O., Bolourani, P., and Devreotes, P.N. (2008). PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol 18, 1034–1043 .
doi: 10.1016/j.cub.2008.06.068
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Kamimura, Y., and Devreotes, P.N. (2010). Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. J Biol Chem 285, 7938–7946 .
doi: 10.1074/jbc.M109.089235
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Lee, S., Comer, F.I., Sasaki, A., McLeod, I.X., Duong, Y., Okumura, K., Yates, J.R., Parent, C.A., and Firtel, R.A. (2005). TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell 16, 4572–4583 .
doi: 10.1091/mbc.E05-04-0342
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