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Prot Cell    2012, Vol. 3 Issue (7) : 497-507    https://doi.org/10.1007/s13238-012-0042-0      PMID: 22773340
REVIEW
Functional regulation of monocyte-derived dendritic cells by microRNAs
Yifan Zhan1,2(), Li Wu3
1. The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; 2. Department of Medical Biology, University of Melbourne, Parkville 3010, Australia; 3. Tsignhua University and Peking University Joint Center for Life Sciences and Tsinghua University School of Medicine, Beijing 100084, China
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Abstract

Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent producers of pro-inflammatory cytokines and potent inducers of T helper differentiation. They behave as a “double-edge” sword so that they not only mediate protective immunity but also immuno-pathology. It is still incompletely understood how their function is regulated. Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area.
Keywords dendritic cells      microRNA      function     
Corresponding Author(s): Zhan Yifan,Email:zhan@wehi.edu.au   
Issue Date: 01 July 2012
 Cite this article:   
Yifan Zhan,Li Wu. Functional regulation of monocyte-derived dendritic cells by microRNAs[J]. Prot Cell, 2012, 3(7): 497-507.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-012-0042-0
https://academic.hep.com.cn/pac/EN/Y2012/V3/I7/497
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