Converted neural cells: induced to a cure?

doi:10.1007/s13238-012-2029-2

Prot Cell

2012, Vol. 3

Issue (2) : 91-97 https://doi.org/10.1007/s13238-012-2029-2 PMID: 22410787

MINI-REVIEW

Converted neural cells: induced to a cure?

Weiqi Zhang¹, Shunlei Duan¹, Ying Li¹, Xiuling Xu¹, Jing Qu¹(

), Weizhou Zhang²(

), Guang-Hui Liu¹(

)

1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; 2. Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA

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Abstract

Many neurodegenerative disorders such as Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and others often occur as a result of progressive loss of structure or function of neurons. Recently, many groups were able to generate neural cells, either differentiated from induced pluripotent stem cells (iPSCs) or converted from somatic cells. Advances in converted neural cells have opened a new era to ease applications for modeling diseases and screening drugs. In addition, the converted neural cells also hold the promise for cell replacement therapy (Kikuchi et al., 2011; Krencik et al., 2011; Kriks et al., 2011; Nori et al., 2011; Rhee et al., 2011; Schwartz et al., 2012). Here we will mainly discuss most recent progress on using converted functional neural cells to treat neurological diseases and highlight potential clinical challenges and future perspectives.

Keywords converted neural cell pluripotent stem cell transdifferentiation transplantation neurodegenerative diseases

Corresponding Author(s): Qu Jing,Email:jqu@salk.edu; Zhang Weizhou,Email:w4zhang@ucsd.edu; Liu Guang-Hui,Email:ghliu@ibp.ac.cn

Issue Date: 01 February 2012

Cite this article:

Weiqi Zhang,Shunlei Duan,Ying Li, et al. Converted neural cells: induced to a cure?[J]. Prot Cell, 2012, 3(2): 91-97.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-012-2029-2
https://academic.hep.com.cn/pac/EN/Y2012/V3/I2/91

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