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Protein & Cell

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ISSN 1674-8018(Online)

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Prot Cell    2013, Vol. 4 Issue (1) : 40-52    https://doi.org/10.1007/s13238-012-2104-8      PMID: 23132256
REVIEW
Regulation of TLR7/9 signaling in plasmacytoid dendritic cells
Musheng Bao(), Yong-Jun Liu()
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
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Abstract

Plasmacytoid dendritic cells (pDCs), also known as type I interferon (IFN)-producing cells, are specialized immune cells characterized by their extraordinary capabilities of mounting rapid and massive type I IFN response to nucleic acids derived from virus, bacteria or dead cells. PDCs selectively express endosomal Toll-like receptor (TLR) 7 and TLR9, which sense viral RNA and DNA respectively. Following type I IFN and cytokine responses, pDCs differentiate into antigen presenting cells and acquire the ability to regulate T cell-mediated adaptive immunity. The functions of pDCs have been implicated not only in antiviral innate immunity but also in immune tolerance, inflammation and tumor microenvironments. In this review, we will focus on TLR7/9 signaling and their regulation by pDC-specific receptors.
Keywords plasmacytoid dendritic cells      Toll-like receptors      immunoreceptor tyrosine-based activation motif      immunoreceptor tyrosine-based inhibitory motif      immunoglobulin-like transcript      BDCA2      phospholipid scramblase 1      protein kinase C and casein kinase substrate in neurons 1     
Corresponding Author(s): Bao Musheng,Email:Musheng.Bao@baylorhealth.edu; Liu Yong-Jun,Email:Yong-Jun.Liu@baylorhealth.edu   
Issue Date: 01 January 2013
 Cite this article:   
Musheng Bao,Yong-Jun Liu. Regulation of TLR7/9 signaling in plasmacytoid dendritic cells[J]. Prot Cell, 2013, 4(1): 40-52.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-012-2104-8
https://academic.hep.com.cn/pac/EN/Y2013/V4/I1/40
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