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Prot Cell    2013, Vol. 4 Issue (11) : 813-819    https://doi.org/10.1007/s13238-013-3085-y      PMID: 24214874
MINI-REVIEW
MicroRNA-21 in the pathogenesis of acute kidney injury
Ya-Feng Li1,2(), Ying Jing3, Jielu Hao4, Nathan C Frankfort5, Xiaoshuang Zhou1,2, Bing Shen6, Xinyan Liu1,2, Lihua Wang1,2, Rongshan Li2,7()
1. Department of Nephrology and Hemodialysis Center, Second Hospital of Shanxi Medical University, Taiyuan 030001, China; 2. Shanxi Renal Disease Research Institution, Taiyuan 030001, China; 3. Department of Blood Purification, General Hospital of Jinan Military Command of PLA, Jinan 250031, China; 4. Nephrology Institute of PLA, Changzheng Hospital of Second Military Medical University, Shanghai 200003, China; 5. Department of Neuroscience and Neurovirology, Temple University School of Medicine, Philadelphia, PA 19140, USA; 6. Department of Urology, Shanghai First People’s Hospital, Shanghai 200080, China; 7. Department of Nephrology and Hemodialysis Center, Shanxi Provincial People’s Hospital, Taiyuan 030012, China
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Abstract

Acute kidney injury (AKI), associated with significant morbidity and mortality, is widely known to involve epithelial apoptosis, excessive inflammation, and fibrosis in response to ischemia or reperfusion injury, which results in either chronic pathological changes or death. Therefore, it is imperative that investigations are conducted in order to find effective, early diagnoses, and therapeutic targets needed to help prevent and treat AKI. However, the mechanisms modulating the pathogenesis of AKI still remain largely undetermined. MicroRNAs (miRNAs), small noncoding RNA molecules, play an important role in several fundamental biological and pathological processes by a post transcriptional regulatory function of gene expression. MicroRNA-21 (miR-21) is a recently identified, typical miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fibrotic signaling pathways in AKI. As a result, miR-21 is now considered a novel biomarker when diagnosing and treating AKI. This article reviews the correlative literature and research progress regarding the roles of miR-21 in AKI.
Keywords microRNA      microRNA-21      gene expression      acute kidney injury     
Corresponding Author(s): Li Ya-Feng,Email:Dr.yafengli@gmail.com; Li Rongshan,Email:rongshanli@126.com   
Issue Date: 01 November 2013
 Cite this article:   
Ya-Feng Li,Ying Jing,Jielu Hao, et al. MicroRNA-21 in the pathogenesis of acute kidney injury[J]. Prot Cell, 2013, 4(11): 813-819.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-013-3085-y
https://academic.hep.com.cn/pac/EN/Y2013/V4/I11/813
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