CRISPR/Cas9 and TALE: beyond cut and paste

doi:10.1007/s13238-015-0137-5

Protein Cell

2015, Vol. 6

Issue (3) : 157-159 https://doi.org/10.1007/s13238-015-0137-5

PERSPECTIVE

CRISPR/Cas9 and TALE: beyond cut and paste

Liping Deng¹,Ruotong Ren¹,Jun Wu²,Keiichiro Suzuki²,Juan Carlos Izpisua Belmote^2,^*(

),Guang-Hui Liu^1,^3,^4,^*(

)

1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
2. Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
3. Beijing Institute for Brain Disorders, Beijing 100069, China
4. Center for Molecular and Translational Medicine, CMTM, Beijing 100101, China

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Abstract

Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.

Keywords TALE CRISPR/Cas9 genome editing gene expression transcription regulation

Corresponding Author(s): Juan Carlos Izpisua Belmote,Guang-Hui Liu

Issue Date: 01 April 2015

Cite this article:

Liping Deng,Ruotong Ren,Jun Wu, et al. CRISPR/Cas9 and TALE: beyond cut and paste[J]. Protein Cell, 2015, 6(3): 157-159.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-015-0137-5
https://academic.hep.com.cn/pac/EN/Y2015/V6/I3/157

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