Role of transcription factor acetylation in the regulation of metabolic homeostasis

doi:10.1007/s13238-015-0204-y

Protein Cell

2015, Vol. 6

Issue (11) : 804-813 https://doi.org/10.1007/s13238-015-0204-y

REVIEW

Role of transcription factor acetylation in the regulation of metabolic homeostasis

Joo-Man Park¹,Seong-Ho Jo¹,Mi-Young Kim¹,Tae-Hyun Kim¹,Yong-Ho Ahn^1,²(

)

1. Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea
2. Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea

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Abstract

Post-translational modifications (PTMs) of transcription factors play a crucial role in regulating metabolic homeostasis. These modifications include phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, and O-GlcNAcylation. Recent studies have shed light on the importance of lysine acetylation at nonhistone proteins including transcription factors. Acetylation of transcription factors affects subcellular distribution, DNA affinity, stability, transcriptional activity, and current investigations are aiming to further expand our understanding of the role of lysine acetylation of transcription factors. In this review, we summarize recent studies that provide new insights into the role of protein lysine-acetylation in the transcriptional regulation of metabolic homeostasis.

Keywords metabolic homeostasis transcription factor post-translational modification type 2 diabetes mellitus

Issue Date: 04 November 2015

Cite this article:

Joo-Man Park,Seong-Ho Jo,Mi-Young Kim, et al. Role of transcription factor acetylation in the regulation of metabolic homeostasis[J]. Protein Cell, 2015, 6(11): 804-813.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-015-0204-y
https://academic.hep.com.cn/pac/EN/Y2015/V6/I11/804

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