Please wait a minute...
Protein & Cell

ISSN 1674-800X

ISSN 1674-8018(Online)

CN 11-5886/Q

Postal Subscription Code 80-984

2018 Impact Factor: 7.575

Protein Cell    2016, Vol. 7 Issue (6) : 450-454    https://doi.org/10.1007/s13238-016-0275-4
LETTER
The crystal structure of Zika virus helicase: basis for antiviral drug design
Hongliang Tian1,2,Xiaoyun Ji3,Xiaoyun Yang1,Wei Xie1,Kailin Yang4,Cheng Chen1,Chen Wu1,Heng Chi1,Zhongyu Mu1,Zefang Wang1,Haitao Yang1,2,*()
1. School of Life Sciences, Tianjin University, Tianjin 300072, China
2. Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China
3. The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210023, China
4. Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
 Download: PDF(1059 KB)  
 Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Corresponding Author(s): Haitao Yang   
Issue Date: 20 June 2016
 Cite this article:   
Hongliang Tian,Xiaoyun Ji,Xiaoyun Yang, et al. The crystal structure of Zika virus helicase: basis for antiviral drug design[J]. Protein Cell, 2016, 7(6): 450-454.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-016-0275-4
https://academic.hep.com.cn/pac/EN/Y2016/V7/I6/450
1 Brasil P, Pereira JP Jr, Raja Gabaglia C, Damasceno L, Wakimoto M, Ribeiro Nogueira RM, Carvalho de Sequeira P, Machado Siqueira A, Abreu de Carvalho LM, Cotrim da Cunha D (2016) Zika virus infection in pregnant women in Rio de Janeiro—preliminary report . N Engl J Med.
https://doi.org/10.1056/NEJMoa1602412
2 Caruthers JM, McKay DB (2002) Helicase structure and mechanism . Curr Opin Struct Biol 12:123–133
https://doi.org/10.1016/S0959-440X(02)00298-1
3 Felsenstein J (1997) An alternating least squares approach to inferring phylogenies from pairwise distances . Syst Biol 46: 101–111
https://doi.org/10.1093/sysbio/46.1.101
4 Hennessey M, Fischer M, Staples JE (2016) Zika virus spreads to new areas—region of the Americas, May 2015-January 2016 . Morb Mortal Wkly Rep 65:55–58
https://doi.org/10.15585/mmwr.mm6503e1
5 Ioos S, Mallet HP, Leparc Goffart I, Gauthier V, Cardoso T, Herida M (2014) Current Zika virus epidemiology and recent epidemics . Med Mal Infect 44:302–307
https://doi.org/10.1016/j.medmal.2014.04.008
6 Lazear HM, Diamond MS (2016) Zika virus: new clinical syndromes and its emergence in the Western Hemisphere . J Virol.
https://doi.org/10.1128/JVI.00252-16
7 Lindenbach BD, Rice CM (2001) Fundamental virology . Lippincott-Raven, Philadelphia
8 Luo D, Xu T, Watson RP, Scherer-Becker D, Sampath A, Jahnke W, Yeong SS, Wang CH, Lim SP, Strongin A (2008) Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein . EMBO J 27:3209–3219
https://doi.org/10.1038/emboj.2008.232
9 Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, Kolenc M, Resman Rus K, Vesnaver Vipotnik T, Fabjan Vodusek V (2016) Zika virus associated with microcephaly . N Engl J Med 374:951–958
https://doi.org/10.1056/NEJMoa1600651
10 Pierson TC, Diamond (2013) Flaviviruses, vol 2, 6th edn. Wolter Kluwer, Philadelphia Rodrigues LC (2016) Microcephaly and Zika virus infection . Lancet.
https://doi.org/10.1016/S0140-6736(16)00742-X
11 Stuart DI, Levine M, Muirhead H, Stammers DK (1979) Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å . J Mol Biol 134:109–142
https://doi.org/10.1016/0022-2836(79)90416-9
12 Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM (2016) Zika virus infects human cortical neural progenitors and attenuates their growth . Cell Stem Cell.
https://doi.org/10.1016/j.stem.2016.02.016
13 Xu T, Sampath A, Chao A, Wen D, Nanao M, Chene P, Vasudevan SG, Lescar J (2005) Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 Å . J Virol 79:10278–10288
https://doi.org/10.1128/JVI.79.16.10278-10288.2005
[1] PAC-0450-16911-YHT_suppl_1 Download
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed