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Protein Cell    2017, Vol. 8 Issue (12) : 878-895    https://doi.org/10.1007/s13238-017-0379-5
REVIEW
Guards at the gate: physiological and pathological roles of tissue-resident innate lymphoid cells in the lung
Hang Cheng1,2, Chengyan Jin3, Jing Wu1, Shan Zhu1, Yong-Jun Liu1,4(), Jingtao Chen1()
1. Institute of Translational Medicine, The First Hospital, Jilin University, Changchun 130061, China
2. Department of Pediatrics, The First Hospital, Jilin University, Changchun 130021, China
3. Department of Thoracic Surgery, The Second Hospital, Jilin University, Changchun 130041, China
4. Sanofi Research and Development, Cambridge, MA 02139, USA
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Abstract

The lung is an important open organ and the primary site of respiration. Many life-threatening diseases develop in the lung, e.g., pneumonia, asthma, chronic obstructive pulmonary diseases (COPDs), pulmonary fibrosis, and lung cancer. In the lung, innate immunity serves as the frontline in both anti-irritant response and anti-tumor defense and is also critical for mucosal homeostasis; thus, it plays an important role in containing these pulmonary diseases. Innate lymphoid cells (ILCs), characterized by their strict tissue residence and distinct function in the mucosa, are attracting increased attention in innate immunity. Upon sensing the danger signals from damaged epithelium, ILCs activate, proliferate, and release numerous cytokines with specific local functions; they also participate in mucosal immunesurveillance, immune-regulation, and homeostasis. However, when their functions become uncontrolled, ILCs can enhance pathological states and induce diseases. In this review, we discuss the physiological and pathological functions of ILC subsets 1 to 3 in the lung, and how the pathogenic environment affects the function and plasticity of ILCs.
Keywords lung      innate lymphoid cells      pulmonary diseases      regional immunity     
Corresponding Author(s): Yong-Jun Liu,Jingtao Chen   
Issue Date: 27 December 2017
 Cite this article:   
Hang Cheng,Chengyan Jin,Jing Wu, et al. Guards at the gate: physiological and pathological roles of tissue-resident innate lymphoid cells in the lung[J]. Protein Cell, 2017, 8(12): 878-895.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-017-0379-5
https://academic.hep.com.cn/pac/EN/Y2017/V8/I12/878
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