TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization

doi:10.1007/s13238-017-0395-5

Protein Cell

2017, Vol. 8

Issue (9) : 644-661 https://doi.org/10.1007/s13238-017-0395-5

REVIEW

TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization

Olivier Gouin^1,², Killian L’Herondelle¹, Nicolas Lebonvallet¹, Christelle Le Gall-Ianotto¹, Mehdi Sakka¹, Virginie Buhé¹, Emmanuelle Plée-Gautier¹, Jean-Luc Carré¹, Luc Lefeuvre², Laurent Misery¹(

), Raphaele Le Garrec¹

¹. Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200 Brest, France
². Uriage Dermatological Laboratories, 92400 Courbevoie, France

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Abstract

Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations are mainly sensory and vascular disorders such as pruritus and erythema. Transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively) are non-selective cation channels known to specifically participate in pain and CNI. Both TRPV1 and TRPA1 are co-expressed in a large subset of sensory nerves, where they integrate numerous noxious stimuli. It is now clear that the expression of both channels also extends far beyond the sensory nerves in the skin, occuring also in keratinocytes, mast cells, dendritic cells, and endothelial cells. In these non-neuronal cells, TRPV1 and TRPA1 also act as nociceptive sensors and potentiate the inflammatory process. This review discusses the role of TRPV1 and TRPA1 in the modulation of inflammatory genes that leads to or maintains CNI in sensory neurons and non-neuronal skin cells. In addition, this review provides a summary of current research on the intracellular sensitization pathways of both TRP channels by other endogenous inflammatory mediators that promote the self-maintenance of CNI.

Keywords sensory nerve neurogenic skin inflammation inflammatory gene regulation pruritus

Corresponding Author(s): Laurent Misery

Issue Date: 20 September 2017

Cite this article:

Olivier Gouin,Killian L’Herondelle,Nicolas Lebonvallet, et al. TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization[J]. Protein Cell, 2017, 8(9): 644-661.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-017-0395-5
https://academic.hep.com.cn/pac/EN/Y2017/V8/I9/644

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