Structural and functional roles of ether lipids

doi:10.1007/s13238-017-0423-5

Protein Cell

2018, Vol. 9

Issue (2) : 196-206 https://doi.org/10.1007/s13238-017-0423-5

REVIEW

Structural and functional roles of ether lipids

John M. Dean, Irfan J. Lodhi(

)

Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA

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Abstract

Ether lipids, such as plasmalogens, are peroxisomederived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. This seemingly simple biochemical change has profound structural and functional implications. Notably, the tendency of ether lipids to form non-lamellar inverted hexagonal structures in model membranes suggests that they have a role in facilitating membrane fusion processes. Ether lipids are also important for the organization and stability of lipid raft microdomains, cholesterol-rich membrane regions involved in cellular signaling. In addition to their structural roles, a subset of ether lipids are thought to function as endogenous antioxidants, and emerging studies suggest that they are involved in cell differentiation and signaling pathways. Here, we review the biology of ether lipids and their potential significance in human disorders, including neurological diseases, cancer, and metabolic disorders.

Keywords ether lipids plasmalogen phospholipid peroxisomes cancer metabolic disorders

Corresponding Author(s): Irfan J. Lodhi

Issue Date: 22 March 2018

Cite this article:

John M. Dean,Irfan J. Lodhi. Structural and functional roles of ether lipids[J]. Protein Cell, 2018, 9(2): 196-206.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-017-0423-5
https://academic.hep.com.cn/pac/EN/Y2018/V9/I2/196

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