Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade

doi:10.1007/s13238-018-0596-6

Protein Cell

2019, Vol. 10

Issue (7) : 496-509 https://doi.org/10.1007/s13238-018-0596-6

RESEARCH ARTICLE

Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade

Jiaxing Cui¹, Hongfei Cui^1,³, Mingran Yang¹, Shiyu Du², Junfeng Li¹, Yingxue Li¹, Liyang Liu¹, Xuegong Zhang^1,⁴(

), Shao Li^1,⁴(

)

¹. MOE Key Laboratory of Bioinformatics and TCM-X center/Bioinformatics Division, BNRist/Department of Automation, Tsinghua University, Beijing 100084, China
². China-Japan Friendship Hospital, Beijing 100029, China
³. Institute for Artificial Intelligence and Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China
⁴. School of Life Sciences and Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China

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Abstract

The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progress. In this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrence and development of gastritis. Twenty-one microbial species were identified for differentiating tongue-coating microbiomes of gastritis and healthy individuals. Pathways such as microbial metabolism in diverse environments, biosynthesis of antibiotics and bacterial chemotaxis were up-regulated in gastritis patients. The abundance of Campylobacter concisus was found associated with the gastric precancerous cascade. Furthermore, Campylobacter concisus could be detected in tongue coating and gastric fluid in a validation cohort containing 38 gastritis patients. These observations provided biological evidence of tongue diagnosis in traditional Chinese medicine, and indicated that tongue-coating microbiome could be a potential non-invasive biomarker, which might be suitable for long-term monitoring of gastritis.

Keywords gastritis tongue coating metagenomics Campylobacter concisus non-invasive biomarker

Corresponding Author(s): Xuegong Zhang,Shao Li

Issue Date: 25 July 2019

Cite this article:

Jiaxing Cui,Hongfei Cui,Mingran Yang, et al. Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade[J]. Protein Cell, 2019, 10(7): 496-509.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-018-0596-6
https://academic.hep.com.cn/pac/EN/Y2019/V10/I7/496

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