|
|
|
SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis |
Cuiping Zhang1,2, Ke Wang1, Zuojian Hu2, Lujie Yang1, Bin Wei3, Shan Li2, Xue Qin2, Pengyuan Yang1,5( ), Hongxiu Yu1,4() |
1. Minhang Hospital Institutes of Biomedical Sciences, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
2. Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
3. School of Life Science, Shanghai University, Shanghai 200444, China
4. Minhang Hospital Institutes of Biomedical Sciences, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Fudan University, Room 501, Mingdao Building, 131 Dongan Road, Shanghai 200032, China
5. Minhang Hospital Institutes of Biomedical Sciences, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Fudan University, Room 201, Mingdao Building, 131 Dongan Road, Shanghai 200032, China |
|
|
|
|
|
|
Corresponding Author(s):
Pengyuan Yang,Hongxiu Yu
|
|
Online First Date: 14 September 2020
Issue Date: 07 December 2020
|
|
| 1 |
E Dror, E Dalmas, DT Meier, S Wueest, J Thevenet, C Thienel, K Timper, TM Nordmann, S Traub, F Schulzeet al. (2017) Postprandial macrophage-derived IL-1beta stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol 18:283–292
https://doi.org/10.1038/ni.3659
|
| 2 |
C Hajmrle, N Smith, AF Spigelman, X Dai, L Senior, A Bautista, M Ferdaoussi, PE MacDonald (2016) Interleukin-1 signaling contributes to acute islet compensation. JCI Insight 1:e86055
https://doi.org/10.1172/jci.insight.86055
|
| 3 |
H Hao, L Cao, C Jiang, Y Che, S Zhang, S Takahashi, G Wang, FJ Gonzalez (2017) Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis. Cell Metab 25(856–867):e855
https://doi.org/10.1016/j.cmet.2017.03.007
|
| 4 |
T Heinonen, E Ciarlo, C Theroude, A Pelekanou, J Herderschee, D LeRoy, T Roger (2018) Sirtuin 5 deficiency does not compromise innate immune responses to bacterial infections. Front Immunol 9:2675
https://doi.org/10.3389/fimmu.2018.02675
|
| 5 |
TF Liu, VT Vachharajani, BK Yoza, CE McCall (2012) NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem 287:25758–25769
https://doi.org/10.1074/jbc.M112.362343
|
| 6 |
GD Norata, G Caligiuri, T Chavakis, G Matarese, MG Netea, A Nicoletti, LA O’Neill, FM Marelli-Berg (2015) The cellular and molecular basis of translational immunometabolism. Immunity 43:421–434
https://doi.org/10.1016/j.immuni.2015.08.023
|
| 7 |
K Schroder, J Tschopp (2010) The inflammasomes. Cell 140:821–832
https://doi.org/10.1016/j.cell.2010.01.040
|
| 8 |
M Sestan, S Marinovic, I Kavazovic, D Cekinovic, S Wueest, T Turk Wensveen , I Brizic, S Jonjic, D Konrad, FM Wensveenet al. (2018) Virus-induced interferon-gamma causes insulin resistance in skeletal muscle and derails glycemic control in obesity. Immunity 49(164–177):e166
https://doi.org/10.1016/j.immuni.2018.05.005
|
| 9 |
JP Ting, SB Willingham, DT Bergstralh(2008)NLRs at the intersection of cell death and immunity. Nat Rev Immunol 8:372–379
https://doi.org/10.1038/nri2296
|
| 10 |
S Tsai, X Clemente-Casares, AC Zhou, H Lei, JJ Ahn, YT Chan, O Choi, H Luck, M Woo, SE Dunnet al. (2018) Insulin receptormediated stimulation boosts T cell immunity during inflammation and infection. Cell Metab 28(922–934):e924
https://doi.org/10.1016/j.cmet.2018.08.003
|
| 11 |
TM Tucey, J Verma, PF Harrison, SL Snelgrove, TL Lo, AK Scherer, AA Barugahare, DR Powell, RT Wheeler, MJ Hickeyet al. (2018) glucose homeostasis is important for immune cell viability during candida challenge and host survival of systemic fungal infection. Cell Metab 27(988–1006):e1007
https://doi.org/10.1016/j.cmet.2018.03.019
|
| 12 |
VT Vachharajani, T Liu, X Wang, JJ Hoth, BK Yoza, CE McCall (2016) Sirtuins link inflammation and metabolism. J Immunol Res 2016:8167273
https://doi.org/10.1155/2016/8167273
|
| 13 |
F Wang, K Wang, W Xu, S Zhao, D Ye, Y Wang, Y Xu, L Zhou, Y Chu, C Zhanget al. (2017) SIRT5 desuccinylates and activates pyruvate kinaseM2to block macrophage IL-1beta production and to prevent DSS-induced colitis in mice. Cell Rep 19:2331–2344
https://doi.org/10.1016/j.celrep.2017.05.065
|
| 14 |
H Wen, D Gris, Y Lei, S Jha, L Zhang, MT Huang, WJ Brickey, JP Ting (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12:408–415
https://doi.org/10.1038/ni.2022
|
| 15 |
L Zhong, A D’Urso, D Toiber, C Sebastian, RE Henry, DD Vadysirisack, A Guimaraes, B Marinelli, JD Wikstrom, T Niret al. (2010) The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 140:280–293
https://doi.org/10.1016/j.cell.2009.12.041
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
