Cellular metabolism and homeostasis in pluripotency regulation

doi:10.1007/s13238-020-00755-1

Protein Cell

2020, Vol. 11

Issue (9) : 630-640 https://doi.org/10.1007/s13238-020-00755-1

REVIEW

Cellular metabolism and homeostasis in pluripotency regulation

Kun Liu^1,^2,³, Jiani Cao^1,², Xingxing Shi^1,^2,³, Liang Wang^1,^2,³, Tongbiao Zhao^1,^2,³(

)

¹. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
². Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
³. University of Chinese Academy of Sciences, Beijing 100049, China

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Abstract

Pluripotent stem cells (PSCs) can immortally self-renew in culture with a high proliferation rate, and they possess unique metabolic characteristics that facilitate pluripotency regulation. Here, we review recent progress in understanding the mechanisms that link cellular metabolism and homeostasis to pluripotency regulation, with particular emphasis on pathways involving amino acid metabolism, lipid metabolism, the ubiquitin-proteasome system and autophagy. Metabolism of amino acids and lipids is tightly coupled to epigenetic modification, organelle remodeling and cell signaling pathways for pluripotency regulation. PSCs harness enhanced proteasome and autophagy activity to meet the material and energy requirements for cellular homeostasis. These regulatory events reflect a fine balance between the intrinsic cellular requirements and the extrinsic environment. A more complete understanding of this balance will pave new ways to manipulate PSC fate.

Keywords autophagy amino acid metabolism lipidmetabolism pluripotent stem cell (PSC) ubiquitinproteasome system (UPS)

Corresponding Author(s): Tongbiao Zhao

Issue Date: 25 September 2020

Cite this article:

Kun Liu,Jiani Cao,Xingxing Shi, et al. Cellular metabolism and homeostasis in pluripotency regulation[J]. Protein Cell, 2020, 11(9): 630-640.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-020-00755-1
https://academic.hep.com.cn/pac/EN/Y2020/V11/I9/630

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