Metabolic reprogramming and epigenetic modifications on the path to cancer

doi:10.1007/s13238-021-00846-7

Protein Cell

2022, Vol. 13

Issue (12) : 877-919 https://doi.org/10.1007/s13238-021-00846-7

REVIEW

Metabolic reprogramming and epigenetic modifications on the path to cancer

Linchong Sun¹(

), Huafeng Zhang^2,³(

), Ping Gao^1,^4,⁵(

)

¹. Guangzhou First People’s Hospital, School of Medicine, Institutes for Life Sciences, South China University of Technology, Guangzhou 510006, China
². The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230027, China
³. CAS Centre for Excellence in Cell and Molecular Biology, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China
⁴. School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 510006, China
⁵. Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China

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Abstract

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally regulate each other, are among the well-known cancer hallmarks. Recent evidence suggests that many metabolites serve as substrates or cofactors of chromatin-modifying enzymes as a consequence of the translocation or spatial regionalization of enzymes or metabolites. Various metabolic alterations and epigenetic modifications also reportedly drive immune escape or impede immunosurveillance within certain contexts, playing important roles in tumor progression. In this review, we focus on how metabolic reprogramming of tumor cells and immune cells reshapes epigenetic alterations, in particular the acetylation and methylation of histone proteins and DNA. We also discuss other eminent metabolic modifications such as, succinylation, hydroxybutyrylation, and lactylation, and update the current advances in metabolismand epigenetic modification-based therapeutic prospects in cancer.

Keywords metabolic reprogramming epigenetics tumorigenesis tumor immunity cancer therapy

Corresponding Author(s): Linchong Sun,Huafeng Zhang,Ping Gao

Online First Date: 30 July 2021 Issue Date: 22 December 2022

Cite this article:

Linchong Sun,Huafeng Zhang,Ping Gao. Metabolic reprogramming and epigenetic modifications on the path to cancer[J]. Protein Cell, 2022, 13(12): 877-919.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-021-00846-7
https://academic.hep.com.cn/pac/EN/Y2022/V13/I12/877

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