Synthetic gene circuits moving into the clinic

doi:10.15302/J-QB-021-0234

Quantitative Biology

2021, Vol. 9

Issue (1): 100-103 https://doi.org/10.15302/J-QB-021-0234

本期目录

Synthetic gene circuits moving into the clinic

Shuguang Peng¹, Huiya Huang², Ping Wei³, Zhen Xie¹(

)

¹. MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, Department of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing 100084, China
². Beijing Syngentech Co., Ltd, Zhongguancun Life Science Park, Changping District, Beijing 102206, China
³. Center for Gene Circuit and Cell Design, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China

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收稿日期: 2020-12-29 出版日期: 2021-03-31

Corresponding Author(s): Zhen Xie

引用本文:

. [J]. Quantitative Biology, 2021, 9(1): 100-103.
Shuguang Peng, Huiya Huang, Ping Wei, Zhen Xie. Synthetic gene circuits moving into the clinic. Quant. Biol., 2021, 9(1): 100-103.

链接本文:

https://academic.hep.com.cn/qb/CN/10.15302/J-QB-021-0234
https://academic.hep.com.cn/qb/CN/Y2021/V9/I1/100

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1	V. M. Isabella, , B. N. Ha, , M. J. Castillo, , D. J. Lubkowicz, , S. E. Rowe, , Y. A. Millet, , C. L. Anderson, , N. Li, , A. B. Fisher, , K. A. West, , et al. (2018) Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria. Nat. Biotechnol., 36, 857–864 https://doi.org/10.1038/nbt.4222 pmid: 30102294
2	J. H. Esensten, , J. A. Bluestone, and W. A. Lim, (2017) Engineering therapeutic T cells: from synthetic biology to clinical trials. Annu. Rev. Pathol., 12, 305–330 https://doi.org/10.1146/annurev-pathol-052016-100304 pmid: 27959633
3	M. Tigges, , T. T. Marquez-Lago, , J. Stelling, and M. Fussenegger, (2009) A tunable synthetic mammalian oscillator. Nature, 457, 309–312 https://doi.org/10.1038/nature07616 pmid: 19148099
4	T. S. Gardner, , C. R. Cantor, and J. J. Collins, (2000) Construction of a genetic toggle switch in Escherichia coli. Nature, 403, 339–342 https://doi.org/10.1038/35002131 pmid: 10659857
5	A. E. Friedland, , T. K. Lu, , X. Wang, , D. Shi, , G. Church, and J. J. Collins, (2009) Synthetic gene networks that count. Science, 324, 1199–1202 https://doi.org/10.1126/science.1172005 pmid: 19478183
6	Z. Xie, , L. Wroblewska, , L. Prochazka, , R. Weiss, and Y. Benenson, (2011) Multi-input RNAi-based logic circuit for identification of specific cancer cells. Science, 333, 1307–1311 https://doi.org/10.1126/science.1205527 pmid: 21885784
7	H. Huang, , Y. Liu, , W. Liao, , Y. Cao, , Q. Liu, , Y. Guo, , Y. Lu, and Z. Xie, (2019) Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy. Nat. Commun., 10, 4801 https://doi.org/10.1038/s41467-019-12794-2 pmid: 31641136
8	L. Nissim, , M. R. Wu, , E. Pery, , A. Binder-Nissim, , H. I. Suzuki, , D. Stupp, , C. Wehrspaun, , Y. Tabach, , P. A. Sharp, and T. K. Lu, (2017) Synthetic RNA-based immunomodulatory gene circuits for cancer immunotherapy. Cell, 171, 1138–1150.e15 https://doi.org/10.1016/j.cell.2017.09.049 pmid: 29056342
9	J. Z. Williams, , G. M. Allen, , D. Shah, , I. S. Sterin, , K. H. Kim, , V. P. Garcia, , G. E. Shavey, , W. Yu, , C. Puig-Saus, , J. Tsoi, , et al. (2020) Precise T cell recognition programs designed by transcriptionally linking multiple receptors. Science, 370, 1099–1104 pmid: 33243890
10	C. Kemmer, , M. Gitzinger, , M. Daoud-El Baba, , V. Djonov, , J. Stelling, and M. Fussenegger, (2010) Self-sufficient control of urate homeostasis in mice by a synthetic circuit. Nat. Biotechnol., 28, 355–360 https://doi.org/10.1038/nbt.1617 pmid: 20351688
11	C. Y. Wu, , K. T. Roybal, , E. M. Puchner, , J. Onuffer, and W. A. Lim, (2015) Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science, 350, aab4077 https://doi.org/10.1126/science.aab4077 pmid: 26405231
12	J. Yin, , L. Yang, , L. Mou, , K. Dong, , J. Jiang, , S. Xue, , Y. Xu, , X. Wang, , Y. Lu, and H. Ye, (2019) A green tea-triggered genetic control system for treating diabetes in mice and monkeys. Sci. Transl. Med., 11, eaav8826 https://doi.org/10.1126/scitranslmed.aav8826 pmid: 31645456
13	H. Ye, , M. Xie, , S. Xue, , G. Charpin-El Hamri, , J. Yin, , H. Zulewski, , & M. Fussenegger, (2017) Self-adjusting synthetic gene circuit for correcting insulin resistance. Nat. Biomed. Eng., 1, 0005
14	D. S. Leventhal, , A. Sokolovska, , N. Li, , C. Plescia, , S. A. Kolodziej, , C. W. Gallant, , R. Christmas, , J. R. Gao, , M. J. James, , A. Abin-Fuentes, , et al. (2020) Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity. Nat. Commun., 11, 2739 https://doi.org/10.1038/s41467-020-16602-0 pmid: 32483165
15	T. Kitada, , B. DiAndreth, , B. Teague, and R. Weiss, (2018) Programming gene and engineered-cell therapies with synthetic biology. Science, 359, eaad1067 pmid: 29439214

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