摘要:Human tissue biobanks have an increasingly important role in transforming medical study designs and is critical for application of a wide range of new technologies(“omics”)to the discovery of molecular patterns of disease and for implementation of novel biomarkers into clinical trials.Although pathologists has patient care as their primary mission in their normal practice of pathology, they do play a vital but often underrecognized role in the operation of these tissue banks.Besides making sure that the timing of all operations is consistent with both the requirements of clinical diagnosis and the optimal preservation of biological products, pathologists are needed to characterize tissues for research, to conduct quality assurance programs, to assist with resource allocation decisions, and to serve an educational role for investigators using the tissues.This article describes these key principles and a set of practice gross pathology guidelines focused on the decision for tissue banking at the time specimens are macroscopically evaluated, where pathologist involvement is crucial to biobank management.In conclusion, pathologists play a critical role in helping biobank users understand the principles of specimen evaluation(histologic and structural composition of tissues, and their limitations)so as to optimize the scientific benefit of the tissues.We believe that appreciation of these principles will facilitate the partnership between surgical pathologists and biobank directors, enhance the value of research on non renewable resources of biological samples, and at the same time, optimize the operational standardization of biological sample collection procedures in clinical pathology.
出版日期: 2015-03-02
引用本文:
Yanhong Tai,Xia Xia,Zhao Jiang,Bo zhang,Qiuhong Man,Hong Zhang. Treatment of lower limb ischemia by autologous stem cell transplantation: present clinical transformation and future development[J]. 转化医学研究, 2014, 4(4): 133-133.