Please wait a minute...
转化医学研究
“中国核心期刊(遴选)数据库”收录期刊
“万方数据—数字化期刊群”全文入网期刊
“中国学术期刊网络出版总库”及CNKI系列数据库收录期刊
“中文科技期刊数据库”收录期刊
转化医学研究  2014, Vol. 4 Issue (4): 87-87   https://doi.org/10.3868/j.issn.2095-154x.2015.01.009EN
  化学前言 本期目录
The gestational exposure in rats to clozapine promotes the spatial learning and memory and increases the phosphorylation of MAPK42 in the hippocampus of the adult offspring
Haiyan Zeng1,Guangyu Ma2,Liqian Cui2,Zha oTang3,Wenqiang Wang1*
1.Xianyue Hospital of Xiamen, Xiamen 361012, China
2.The Mental Health Center, Shantou University Medical College, Shantou 515041, China
3.Department of Pharmacology, Shantou University Medical College, Shantou 515041, China
The gestational exposure in rats to clozapine promotes the spatial learning and memory and increases the phosphorylation of MAPK42 in the hippocampus of the adult offspring
 全文: PDF(763 KB)  
摘要:Objective The aim of this study was to examine the effect of gestational exposure to the antipsychotic clozapine in rats on the spatial learning and memory of adult offspring and to explore the underlying mechanism.Method During the middle period (G6-15) of gestation, pregnant female rats received intraperitoneal injection of clozapine (10 mg/kg) once a day.When growing into 8 week old, the males of the offspring were subjected to Morris water maze test to measure their spatial learning and memory.Their brain tissue was processed for Western blot analysis to assess levels of MAPK44/42 and phosphorylated MAPK44/42, and real time PCR to evaluate the expression of zif 268 gene Result The offspring with the history of prenatal exposure to clozapine showed better performance in the Morris water maze compared with the controls Western blot analysis showed a significant higher level of pMAPK 42 in the hippocampus of rats in the clozapine group, whereas no difference was found between the two groups in terms of the other indices.Conclusion These results suggest an important role of the MAPK42 phosphorylation in the promotion of the spatial learning and memory of adult offspring by clozapine given to pregnant female rats during the middle period of gestation
出版日期: 2015-04-22
 引用本文:   
Haiyan Zeng,Guangyu Ma,Liqian Cui,Zha oTang,Wenqiang Wang. The gestational exposure in rats to clozapine promotes the spatial learning and memory and increases the phosphorylation of MAPK42 in the hippocampus of the adult offspring[J]. 转化医学研究, 2014, 4(4): 87-87.
 链接本文:  
https://academic.hep.com.cn/tmr/CN/Y2014/V4/I4/87
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed