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Strategies for enhancing DNA vaccine potency
by targeting antigen-presenting cells |
Xingxing WANG1,Fei ZHONG1,Nan LI1,Dongmei HAN1,Sumin PAN1,Xiujin LI2, |
1.Department of Basic
Veterinary Medicine, College of Animal Science and Technology, Agricultural
University of Hebei, Baoding 071001, China; 2.Department of Biotechnology,
College of Environmental and Chemical Engineering, Yanshan University,
Qinhuangdao 066064, China; |
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Abstract The potency of DNA vaccines to stimulate the immune response, especially the T-cell immune response against viral infections and tumors, depends mainly on the ability of antigen-presenting cells to process and present DNA-encoded antigens. Targeting the specific antigen to antigen-presenting cells is believed to be a crucial step for eliciting the T-cell response. Many strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells have been developed. In this article, we generally introduce a T cell immune system and reviewe some strategies that recently develop for enhancing DNA vaccine potency.
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Keywords
DNA vaccine
antigen presenting cells
targeting
immune response
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Issue Date: 05 December 2009
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