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Frontiers of Agriculture in China

ISSN 1673-7334

ISSN 1673-744X(Online)

CN 11-5729/S

Front. Agric. China    2009, Vol. 3 Issue (4) : 478-485     DOI: 10.1007/s11703-009-0073-3
Research articles |
Strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells
Xingxing WANG1,Fei ZHONG1,Nan LI1,Dongmei HAN1,Sumin PAN1,Xiujin LI2,
1.Department of Basic Veterinary Medicine, College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001, China; 2.Department of Biotechnology, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066064, China;
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Abstract  The potency of DNA vaccines to stimulate the immune response, especially the T-cell immune response against viral infections and tumors, depends mainly on the ability of antigen-presenting cells to process and present DNA-encoded antigens. Targeting the specific antigen to antigen-presenting cells is believed to be a crucial step for eliciting the T-cell response. Many strategies for enhancing DNA vaccine potency by targeting antigen-presenting cells have been developed. In this article, we generally introduce a T cell immune system and reviewe some strategies that recently develop for enhancing DNA vaccine potency.
Keywords DNA vaccine      antigen presenting cells      targeting      immune response      
Issue Date: 05 December 2009
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