Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones

doi:10.1007/s11705-009-0004-0

Front Chem Eng Chin

2009, Vol. 3

Issue (2) : 186-191 https://doi.org/10.1007/s11705-009-0004-0

RESEARCH ARTICLE

Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones

Hua CHEN¹(

), Yanan LI¹, Jie BAI¹, Lian ZHAO¹, Xiangguo YUAN¹, Xiaoliu LI^1,2(

), Keqiang CAO³

1. Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, China; 2. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding,071002, China; 3. College of Plant Protection,Agricultural University, Baoding, Hebei 071001, China

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Abstract

2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones 4 and 5 were synthesized in 41%-67% yield by using microwave-assisted one-pot protocol. The structures of the new compounds 4l, 4m, 5c, 5e, 5g, 5h, and 5j-5m were confirmed by IR, NMR, MS, and elemental analysis. The antimicrobial activities of the compounds against Pseudomonas syringae pv. lachrymans (Smith et Bryan) Young, Dye & Wilkie, Botrytis cinerea Pers., and Sphaerotheca fusca Blum. were examined. Some of the compounds showed good antifungical activity against Sphaerotheca fusca Blum.

Keywords microwave-assisted synthesis naphthyl thiazolidin-4-one antimicrobial

Corresponding Author(s): CHEN Hua,Email:hua-todd@hbu.cn; LI Xiaoliu,Email:lixl@hbu.cn

Issue Date: 05 June 2009

Cite this article:

Xiangguo YUAN,Xiaoliu LI,Keqiang CAO, et al. Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones[J]. Front Chem Eng Chin, 2009, 3(2): 186-191.

URL:

https://academic.hep.com.cn/fcse/EN/10.1007/s11705-009-0004-0
https://academic.hep.com.cn/fcse/EN/Y2009/V3/I2/186

Fig.1 Condition 1 for : M.W., toluene, 140°C in 10 mL sealed vessel, 5 min
Condition 2 for : M.W., toluene, reflux, 20 min
Scheme 1 Microwave assisted synthesis of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones

Tab.1 Inhibition of compounds on Blum

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