Optimization of microwave-assisted extraction for picroside I and picroside II from <i>Picrorrhiza kurroa</i> using Box-Behnken experimental design

doi:10.1007/s11705-014-1458-2

Front. Chem. Sci. Eng.

2014, Vol. 8

Issue (4) : 445-453 https://doi.org/10.1007/s11705-014-1458-2

RESEARCH ARTICLE

Optimization of microwave-assisted extraction for picroside I and picroside II from Picrorrhiza kurroa using Box-Behnken experimental design

Pravin WAKTE(

),Ajit PATIL,Bhusari SACHIN,Munnaza QUAZI,Shraddha JABDE,Devanand SHINDE

Pharmaceutical Technology Division, Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, India

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Abstract

The response surface methodology was employed to study the optimization of microwave-assisted extraction of picroside I and picroside II from Picrorrhiza kurroa Royle rhizomes. The effects of solid to solvent ratio, and extraction temperature, time and solvent on the yields of picroside I and picroside II have been investigated using Box-Behnken experimental design. The experimental data were fitted to second-order polynomial equations using multiple regression analysis and analyzed using the appropriate statistical method. By solving the regression equation and analyzing 3-D plots, the optimum extraction conditions were found to be: solid to solvent ratio, 10 : 90 (w/v); temperature, 60 °C; and extraction time, 60 s. Under the optimal conditions, the yields of picroside I and picroside II are 41.23 and 6.12 mg·g^–1 feed respectively, which are in good agreement with the predicted values. The ratio of solid to solvent significantly affects the yields of picroside I and picroside II. Application of microwave-assisted extraction of picroside I and picroside II from P. kurroa would dramatically reduce extraction time and solvent consumption.

Keywords Box-Behnken design microwave-assisted extraction picroside I picroside II Picrorrhiza kurroa

Corresponding Author(s): Pravin WAKTE

Online First Date: 31 December 2014 Issue Date: 14 January 2015

Cite this article:

Pravin WAKTE,Ajit PATIL,Bhusari SACHIN, et al. Optimization of microwave-assisted extraction for picroside I and picroside II from Picrorrhiza kurroa using Box-Behnken experimental design[J]. Front. Chem. Sci. Eng., 2014, 8(4): 445-453.

URL:

https://academic.hep.com.cn/fcse/EN/10.1007/s11705-014-1458-2
https://academic.hep.com.cn/fcse/EN/Y2014/V8/I4/445

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