Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

doi:10.1007/s11705-017-1678-3

Front. Chem. Sci. Eng.

2018, Vol. 12

Issue (1) : 184-193 https://doi.org/10.1007/s11705-017-1678-3

RESEARCH ARTICLE

Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

Kimthet Chhouk^1,²(

), Wahyudiono³, Hideki Kanda³, Shin-Ichro Kawasaki⁴, Motonobu Goto³

¹. Department of Chemical Engineering, Nagoya University, Nagoya 464-8603, Japan
². Department of Chemical Engineering and Food Technology, Institute of Technology of Cambodia, Phnom Penh, Cambodia
³. Department of Materials Process Engineering, Nagoya University, Nagoya 464-8603, Japan
⁴. Research Institute for Chemical Engineering Process Technology, National Institute of Advanced Industrial Science and Technology, Sendai 983-8551, Japan

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Abstract

Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and anti-microbial activity. In this work, a swirl mixer was employed to produce the micronized curcumin with polyvinylpyrrolidone (PVP) by the supercritical anti-solvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO₂ flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1:30, feed concentration of 5 mg·mL⁻¹, temperature of 40 °C, pressure of 15 MPa, and CO₂ flow rate of 15 mL·min⁻¹. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.

Keywords micronization curcumin polyvinylpyrrolidone supercritical anti-solvent swirl mixer

Corresponding Author(s): Kimthet Chhouk,Motonobu Goto

Just Accepted Date: 17 August 2017 Online First Date: 03 November 2017 Issue Date: 26 February 2018

Cite this article:

Kimthet Chhouk,Wahyudiono,Hideki Kanda, et al. Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer[J]. Front. Chem. Sci. Eng., 2018, 12(1): 184-193.

URL:

https://academic.hep.com.cn/fcse/EN/10.1007/s11705-017-1678-3
https://academic.hep.com.cn/fcse/EN/Y2018/V12/I1/184

Fig.1 Schematic diagram of the SAS process with a swirl mixer

Fig.2 SEM images of (A) raw curcumin, (B) PVP, and (C) curcumin/PVP particles

Fig.3 Particle size distributions at different operating conditions: (A) curcumin:PVP ratio, (B) concentration, (C) temperature, (D) pressure, and (E) flow rate of CO₂

Fig.4 SEM images of curcumin/PVP particles at feed concentrations of (A) 1:10, (B) 1:20, and (C) 1:30

Fig.5 SEM images of curcumin/PVP particles at feed concentrations of (A) 1 mg·mL⁻¹, (B) 5 mg·mL⁻¹, and (C) 10 mg·mL⁻¹

Fig.6 SEM images of curcumin/PVP particles at temperatures of (A) 30 °C, (B) 40 °C, and (C) 50 °C

Fig.7 SEM images of curcumin/PVP particles at pressures of (A) 10 MPa, (B) 15 MPa, and (C) 20 MPa

Fig.8 SEM image of curcumin/PVP particles at CO₂ flow rate of (A) 10 mL·min⁻¹, (B) 15 mL·min⁻¹, (C) 20 mL·min⁻¹

Fig.9 FTIR spectra of raw curcumin, raw PVP and curcumin/PVP particles

Fig.10 (A) Image of raw curcumin and curcumin/PVP particles and (B) UV spectra of raw curcumin and curcumin/PVP particles in aqueous solution after 12 h

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