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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2009, Vol. 3 Issue (3) : 256-264     DOI: 10.1007/s11684-009-0052-3
Research articles |
Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory to clinic
Pengming SUN PhD, MD 1, Jalid SEHOULI PhD, MD 2, Lihui WEI BM 3,
1.Institute of Gynecologic Oncology, Fujian Provincial Women and Children''s Hospital, Fujian Medical University, Fuzhou 350001, China;Department of Gynecology, Campus Virchow Klinikum, Berlin 13353, Germany; 2.Department of Gynecology, Campus Virchow Klinikum, Berlin 13353, Germany; 3.Department of Gynecology, Peking University People’s Hospital, Beijing 100044, China;
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Abstract  More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic cancer, especially in ovarian cancer. In this article, we systematically review the current targeted therapeutic trials running in clinic. Large, randomized trials have been conducted in the treatment of ovarian cancer, endometrial cancer and cervical cancer by using small molecule, antisense, mutational gene as well as antibodies. Other planned or ongoing trials currentlytargeted at molecular markers which may play important roles in gynecological carcinogenesis andprogression suggest that combination chemotherapy with molecular targeted therapy will ultimately be an importantoption.
Keywords target therapy      gynecologic malignant tumors      clinical trail      molecular medicine      
Issue Date: 05 September 2009
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