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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2011, Vol. 5 Issue (1) : 70-76     DOI: 10.1007/s11684-011-0119-9
REVIEW |
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
Yuan CHEN(), Qi TIAN
Neurobiology Research Center, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, China
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Abstract  

Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ? in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ? functions in vivo, and PKC ? has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ? on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ? could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ? signal pathway in the developing brain.

Keywords protein kinase C ?      signal transduction      neurogenic disease     
Corresponding Authors: CHEN Yuan,Email:cheny33@mail.sysu.edu.cn   
Issue Date: 05 March 2011
URL:  
http://academic.hep.com.cn/fmd/EN/10.1007/s11684-011-0119-9     OR     http://academic.hep.com.cn/fmd/EN/Y2011/V5/I1/70
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