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Hippo pathway in intestinal homeostasis and tumorigenesis |
Lanfen Chen1( ), Funiu Qin1, Xianming Deng1, Joseph Avruch2,3, Dawang Zhou1() |
| 1. State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361005, China; 2. Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; 3. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA |
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Abstract The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death. Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis. Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis, and the crosstalk between the Hippo signaling pathway and other major signaling pathways, i.e. Wnt, Notch and Jak/Stat signaling pathways in intestinal compartment.
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| Keywords
Hippo/Mst1/2
YAP/Yorkie
intestinal stem cells
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Corresponding Author(s):
Chen Lanfen,Email:chenlanfen@xmu.edu.cn; Zhou Dawang,Email:dwzhou@xmu.edu.cn
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Issue Date: 01 April 2012
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