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Frontiers of Agricultural Science and Engineering

ISSN 2095-7505

ISSN 2095-977X(Online)

CN 10-1204/S

邮发代号 80-906

Frontiers of Agricultural Science and Engineering  2018, Vol. 5 Issue (3): 330-339   https://doi.org/10.15302/J-FASE-2018208
  本期目录
Cronobacter spp., foodborne pathogens threatening neonates and infants
Qiming CHEN1,2, Yang ZHU3, Zhen QIN1,2, Yongjun QIU1,2, Liming ZHAO1,2()
1. School of Biotechnology, State Key Laboratory of Bioreactor Engineering, R&D Center of Separation and Extraction Technology in Fermentation Industry, East China University of Science and Technology, Shanghai 200237, China
2. Shanghai Collaborative Innovation Center for Biomanufacturing Technology (SCICBT), Shanghai 200237, China
3. Bioprocess Engineering Group, Agrotechnology and Food Sciences, Wageningen University and Research, 6700 AA Wageningen, the Netherlands
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Abstract

Cronobacter spp. (formerly Enterobacter sakazakii) are special foodborne pathogens. Cronobacter infection can cause necrotizing enterocolitis, sepsis and meningitis in all age groups, especially neonates and infants, with a high fatality of up to 80%, although the infection is rare. Outbreaks of Cronobacter infection are epidemiologically proven to be associated with contaminated powdered infant formula (PIF). Cronobacter spp. can resist dry environments and survive for a long period in food with low water activity. Therefore, Cronobacter spp. have become serious pathogens of neonates and infants, as well as in the dairy industry. In this review, we present the taxonomy, pathogenesis, resistance, detection and control of Cronobacter spp.

Key wordsCronobacter spp.    desiccation resistance    pathogen control    pathogen detection    powdered infant formula
收稿日期: 2017-08-01      出版日期: 2018-07-31
Corresponding Author(s): Liming ZHAO   
 引用本文:   
. [J]. Frontiers of Agricultural Science and Engineering, 2018, 5(3): 330-339.
Qiming CHEN, Yang ZHU, Zhen QIN, Yongjun QIU, Liming ZHAO. Cronobacter spp., foodborne pathogens threatening neonates and infants. Front. Agr. Sci. Eng. , 2018, 5(3): 330-339.
 链接本文:  
https://academic.hep.com.cn/fase/CN/10.15302/J-FASE-2018208
https://academic.hep.com.cn/fase/CN/Y2018/V5/I3/330
Year Location No. of infections/(death) Age Symptoms Source
2006 India 1/(0) 2 months Septicemia NS[21]
2007 India 2/(1) NS Respiratory disease PIF [21]
2008 USA 2/(1) NS Severe brain injury and hydrocephalus NS[22]
2009 India 1/(0) NS Urinary tract infection NS[23]
2013 USA 1/(0) 33 days Bacteremia PIF (possible)[24]
2014 USA 1/(0) 18 days Meningitis and neurological sequelae Non-fortified breast milk[25]
Tab.1  
Time Source Country Reference
2012 Food powers Republic of Korea Chon et al.[43]
2012 Kitchen equipments America Kilonzo-Nthenge et al.[44]
2012 Dry goods Indonesia Gitapratiwi et al.[45]
2012 Food powers and agricultural products Republic of Korea Lee et al.[46]
2012 Environment and food samples Czech Republic Putthana[47]
2013 Spices and herbs Syria Belal et al.[48]
2013 Powdered infant formula and dairy products Egypt El-Gamal et al.[49]
2014 Dry goods Japan Ogihara et al.[50]
2014 Powdered infant formula China Pan et al.[51]
2014 Dairy products Italy Casalinuovo et al.[52]
2014 Vegetables China Chen et al.[53]
2014 Milk powder China Xu et al.[54]
2014 Infant formula foods, cereals, vegetables, fruits China Li et al.[55]
2015 Foods, herbs and environment samples India Singh[56]
2015 Weaning food and water samples China Cui et al.[57]
2015 Instant foods China Xu et al.[58]
2015 Rice flour China Huang et al.[59]
2015 PIF and infant formula production factory China Fei et al.[60]
2015 Pasta Germany Akineden et al.[61]
2016 PIF/Baby food Egypt Abdel-Galil et al.[62]
2016 Baby milk products China Li et al.[63]
2016 Food of plant origin and environmental samples from farms and supermarkets Czech Republic Vojkovska et al.[64]
2017 Retail foods Brazil Brandão et al.[65]
2017 Baby foods and baby food ingredients Turkey Heperkan et al.[66]
Tab.2  
Fig.1  
Target gene Genus/Species Reference
dnaG Genus Seo et al.[92]
gluB Genus Lehner et al.[93]
tRNAGlu Genus Hassan et al.[94]
23S rDNA Genus Derzelle et al.[95]
16S rDNA Genus Hassan et al.[94]
wehC, wehI Species Mullane et al.[96]
zpx Genus Jaradat et al.[97]
wzx Genus Jarvis et al.[98]
gyrB Genus Huang et al.[99]
grxB Genus Dong et al.[100]
ompA Genus Zimmermann et al.[101]
MMS Genus Tan et al.[102]
cgcA Species Hu et al.[103]
rpoB Genus Li et al.[104]
ITS Genus Liu et al.[105]
PapC Species Chen et al.[106]
gluB Species YE et al.[107]
Tab.3  
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